ACL LOSS AND KNEE DYNAMICS IN THE PATHOGENESIS OF OA

OA 发病机制中的 ACL 丢失和膝关节动力学

• 批准号: 2083619
• 负责人: ERIC L RADIN
• 金额: $ 18.82万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-25 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2083619
• 关键词: articular cartilage; disease /disorder proneness /risk; dogs; gait; iatrogenic disease; joint ligament; knee; limb movement; magnetic resonance imaging; musculoskeletal injury; orthopedics; osteoarthritis; pathologic process; postoperative complications; radiography; statistics /biometry

There is great enthusiasm by some for surgical reconstruction of the Anterior Cruciate Ligament (ACL) of the knee. Many who have lost their ACL go on to develop osteoarthrosis. The paradox is that others, following ACL rupture, continue to function without problems, even at the professional athletic level. In addition, although meniscal damage is more common following ACL loss, its role in the pathophysiology of osteoarthrosis after ACL rupture is unclear. We hypothesize that the degree of dynamic instability of the knee after ACL loss varies from individual to individual, and is correlated to the degree of subsequent meniscal damage and the development of osteoarthrosis. Using a canine model of ACL transection, the time history of events which follow ACL loss will be documented to define the relationships between dynamic knee instability, meniscal breakdown, and osteoarthrosis. Knee dynamic instability will be assessed during gait by three dimensional photogrammetric analysis based on a unique high-speed biplanar digital radiography system. Articular and meniscal changes will be determined with MRI. Kinematic and MRI testing will be performed on each of 25 dogs before and serially for two years after ACL transection. The goal of this project is to clarify the importance of altered mechanics on the development of osteoarthrosis of the knee following ACL loss. These findings should have significant clinical implications upon the choice of appropriate care of individuals following ACL injury, creating a rational predictive basis for when to surgically intervene.

有些人对外科重建有很大的热情， 膝关节前交叉韧带（ACL）。许多人失去了 ACL继续发展为骨关节病。矛盾的是， ACL断裂后，即使在 专业运动水平。此外，虽然对身体的损害是 更常见于ACL丧失后，其在 ACL断裂后的骨关节病尚不清楚。 我们假设膝关节动态不稳定的程度 ACL损失因人而异，并且与 随后的破坏程度和发展 骨关节病 使用ACL横断的犬模型， 将记录以下ACL丢失，以定义 动力性膝关节不稳定、踝关节断裂和骨关节病。膝 动态不稳定性将在步态过程中通过三维 基于高速双平面数字摄影测量分析 射线照相系统将确定关节和股骨的变化 MRI的。将对25只犬进行运动学和MRI试验 前交叉韧带切断术前和后两年连续观察。 这个项目的目标是阐明改变的重要性， ACL术后膝关节骨关节病形成的力学机制 损失这些发现应该具有重要的临床意义， ACL损伤后个人的适当护理选择， 为何时进行手术干预创造了一个合理的预测基础。