AN INVESTIGATION OF JOINT DEGENERATION

关节退化的研究

• 批准号: 3155517
• 负责人: ERIC L RADIN
• 金额: $ 20.09万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-03-01 至 1992-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3155517
• 关键词: articular cartilage; biomechanics; bone disorder; bone imaging /visualization /scanning; bone metabolism; cartilage disorder; computer simulation; densitometry; disease /disorder model; electron microscopy; high performance liquid chromatography; histochemistry /cytochemistry; histology; joint disorder; knee; laboratory rabbit; musculoskeletal imaging /visualization /scanning; osteoarthritis; physiologic bone resorption; radionuclide imaging /scanning; radiotracer; scintillation spectrometry; sheep; skeletal stress; synovial membrane; trauma

We plan to study the factors promoting progressive cartilage destruction in animal models of osteoarthrosis (Degenerative Joint Disease) to understand its pathophysiology in order to work toward its prevention. Since the pathology of osteoarthrosis involves destruction of the articular cartilage and the remodeling of the bone adjacent to the joints, we must use in vivo preparations. Because osteoarthrosis mainly affects older individuals and its development involves an interrelationship between a variety of tissues, organ cultures utilizing fetal materials are inappropriate. The effectiveness and reliance of our animal models has been established. The joint tissues are studied biochemically, metabolically and biomechanically. Having identified the initial tissue changes in osteoarthrosis we are now completing our study of the inter-relationships of the changes in bone, cartilage, and synovium to determine what makes joint deterioration progressive. We wish to continue our experiments designed to prevent mechanically induced joint deterioration from becoming progressive. We will use inter-related computer models and experimental models. In the process we are working to identify the threshold insults that provoke osteoarthrosis. Experimentally we will use both mechanical and antimetabolic means to prevent and suppress the critical steps in the development of osteoarthrosis from occurring.

我们计划研究促进软骨进展的因素。 骨关节病(退行性关节)动物模型的破坏 疾病)了解其病理生理学，以便致力于 它的预防。因为骨关节病的病理学包括 关节软骨的破坏和关节的重塑 骨与关节相邻时，一定要用体内制剂。 因为骨关节病主要影响老年人和其 发展涉及到各种因素之间的相互关系 利用胎儿材料的组织和器官培养 不合时宜。我们的动物的有效性和可靠性 建立了相应的模型。对关节组织进行了研究 生物化学、新陈代谢和生物力学。拥有 确定了骨关节病的最初组织变化，我们现在是 完成我们对变化的相互关系的研究 骨、软骨和滑膜，以确定关节的组成 渐进性恶化。我们希望继续我们的实验 旨在防止由机械引起的关节损坏 变得进步。我们将使用相互关联的计算机模型 和实验模型。在这个过程中，我们正在努力确定 引发骨关节病的最低限度的侮辱。试验性的 我们将使用机械和抗代谢手段来预防和 抑制骨关节病发展中的关键步骤 阻止它的发生。

项目成果

The influence of basal cartilage calcification on dynamic juxtaarticular stress transmission.

基底软骨钙化对动态近关节应力传递的影响。

• 发表时间: 1993
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: Anderson,DD;Brown,TD;Radin,EL
• 通讯作者: Radin,EL

Stress wave effects in a finite element analysis of an impulsively loaded articular joint.

• DOI: 10.1243/pime_proc_1991_205_258_02
• 发表时间: 1991-01-01
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Anderson, D D;Brown, T D;Radin, E L
• 通讯作者: Radin, E L