AN INVESTIGATION OF JOINT DEGENERATION

关节退化的研究

• 批准号: 3155512
• 负责人: ERIC L RADIN
• 金额: $ 23.18万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-09-30 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3155512
• 关键词: articular cartilage; biomechanics; bone disorder; bone imaging /visualization /scanning; bone metabolism; cartilage disorder; computer simulation; densitometry; disease /disorder model; electron microscopy; high performance liquid chromatography; histochemistry /cytochemistry; histology; joint disorder; knee; laboratory rabbit; musculoskeletal imaging /visualization /scanning; osteoarthritis; physiologic bone resorption; radionuclide imaging /scanning; radiotracer; scintillation spectrometry; sheep; skeletal stress; synovial membrane; trauma

We plan to study the factors promoting progressive cartilage destruction in animal models of osteoarthrosis (Degenerative Joint Disease) to understand its pathophysiology in order to work toward its prevention. Since the pathology of osteoarthrosis involves destruction of the articular cartilage and the remodeling of the bone adjacent to the joints, we must use in vivo preparations. Because osteoarthrosis mainly affects older individuals and its development involves an interrelationship between a variety of tissues, organ cultures utilizing fetal materials are inappropriate. The effectiveness and reliance of our animal models has been established. The joint tissues are studied biochemically, metabolically and biomechanically. Having identified the initial tissue changes in osteoarthrosis we are now completing our study of the inter-relationships of the changes in bone, cartilage, and synovium to determine what makes joint deterioration progressive. We wish to continue our experiments designed to prevent mechanically induced joint deterioration from becoming progressive. We will use inter-related computer models and experimental models. In the process we are working to identify the threshold insults that provoke osteoarthrosis. Experimentally we will use both mechanical and antimetabolic means to prevent and suppress the critical steps in the development of osteoarthrosis from occurring.

我们计划研究促进软骨进展的因素 骨关节病（退行性关节）动物模型的破坏 疾病），以了解其病理生理学，以便努力 其预防。 由于骨关节病的病理学涉及 关节软骨的破坏和 骨关节附近，我们必须使用体内制剂。 由于骨关节病主要影响老年人， 发展涉及各种因素之间的相互关系， 利用胎儿材料的组织、器官培养物， 不合适 我们的动物的有效性和可靠性 模型已经建立。 研究了关节组织 从生物化学、新陈代谢和生物力学的角度来看。 具有 我们现在发现了骨关节病的最初组织变化 完成我们对变化的相互关系的研究， 骨，软骨和滑膜，以确定是什么使关节 逐渐恶化。 我们希望继续我们的实验 旨在防止机械引起的关节退化， 变得进步。 我们将使用相互关联的计算机模型 和实验模型。 在这个过程中，我们正在努力确定 引发骨关节病的阈值损伤。 实验 我们将使用机械和抗代谢的方法来预防和 抑制骨关节病发展的关键步骤 防止其发生