ACL LOSS AND KNEE DYNAMICS IN THE PATHOGENESIS OF OA

一些人非常热衷于外科手术重建 膝关节前十字韧带(ACL)。许多人失去了他们的 前交叉韧带继续发展为骨关节病。矛盾的是，其他人， 在前交叉韧带断裂后，继续正常工作，即使在 职业运动水平。此外，尽管半月板损伤是 更常见的是在前交叉韧带丧失后，它在前交叉韧带损伤的病理生理学中的作用 前交叉韧带断裂后的骨关节病尚不清楚。 我们假设术后膝关节的动力不稳定程度 前交叉韧带的丢失因个体而异，并与 半月板继发性损伤的程度和发展 骨关节病。 采用犬前交叉韧带横断模型，观察前交叉韧带横断后不同时间段的时程 将记录以下ACL丢失，以定义以下关系 动态膝关节不稳、半月板断裂和骨关节病。膝 在步态过程中，动态不稳定性将通过三维评估 基于独特高速双平面数字相机的摄影测量分析 射线照相系统。将确定关节和半月板的变化 用核磁共振。将对25只狗进行运动学和磁共振成像测试 前交叉韧带横断术前和术后连续两年。 这个项目的目标是阐明改变的重要性 前交叉韧带术后膝关节骨关节病发生发展的力学研究 损失。这些发现应该具有重要的临床意义 前交叉韧带损伤后选择适当的护理， 为何时进行手术干预创造了一个合理的预测基础。

There is great enthusiasm by some for surgical reconstruction of the Anterior Cruciate Ligament (ACL) of the knee. Many who have lost their ACL go on to develop osteoarthrosis. The paradox is that others, following ACL rupture, continue to function without problems, even at the professional athletic level. In addition, although meniscal damage is more common following ACL loss, its role in the pathophysiology of osteoarthrosis after ACL rupture is unclear. We hypothesize that the degree of dynamic instability of the knee after ACL loss varies from individual to individual, and is correlated to the degree of subsequent meniscal damage and the development of osteoarthrosis. Using a canine model of ACL transection, the time history of events which follow ACL loss will be documented to define the relationships between dynamic knee instability, meniscal breakdown, and osteoarthrosis. Knee dynamic instability will be assessed during gait by three dimensional photogrammetric analysis based on a unique high-speed biplanar digital radiography system. Articular and meniscal changes will be determined with MRI. Kinematic and MRI testing will be performed on each of 25 dogs before and serially for two years after ACL transection. The goal of this project is to clarify the importance of altered mechanics on the development of osteoarthrosis of the knee following ACL loss. These findings should have significant clinical implications upon the choice of appropriate care of individuals following ACL injury, creating a rational predictive basis for when to surgically intervene.