ACL LOSS AND KNEE DYNAMICS IN THE PATHOGENESIS OF OA

OA 发病机制中的 ACL 丢失和膝关节动力学

• 批准号: 2517509
• 负责人: ERIC L RADIN
• 金额: $ 18.32万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-25 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2517509
• 关键词: articular cartilage; disease /disorder proneness /risk; dogs; gait; iatrogenic disease; injury; joint ligament; knee; limb movement; magnetic resonance imaging; musculoskeletal injury; orthopedics; osteoarthritis; pathologic process; postoperative complications; radiography; statistics /biometry

There is great enthusiasm by some for surgical reconstruction of the Anterior Cruciate Ligament (ACL) of the knee. Many who have lost their ACL go on to develop osteoarthrosis. The paradox is that others, following ACL rupture, continue to function without problems, even at the professional athletic level. In addition, although meniscal damage is more common following ACL loss, its role in the pathophysiology of osteoarthrosis after ACL rupture is unclear. We hypothesize that the degree of dynamic instability of the knee after ACL loss varies from individual to individual, and is correlated to the degree of subsequent meniscal damage and the development of osteoarthrosis. Using a canine model of ACL transection, the time history of events which follow ACL loss will be documented to define the relationships between dynamic knee instability, meniscal breakdown, and osteoarthrosis. Knee dynamic instability will be assessed during gait by three dimensional photogrammetric analysis based on a unique high-speed biplanar digital radiography system. Articular and meniscal changes will be determined with MRI. Kinematic and MRI testing will be performed on each of 25 dogs before and serially for two years after ACL transection. The goal of this project is to clarify the importance of altered mechanics on the development of osteoarthrosis of the knee following ACL loss. These findings should have significant clinical implications upon the choice of appropriate care of individuals following ACL injury, creating a rational predictive basis for when to surgically intervene.

一些人对手术重建抱有极大的热情 膝盖的前十字韧带（ACL）。许多人失去了自己的 ACL 继续发展为骨关节病。矛盾的是，其他人， ACL 断裂后，即使在 专业运动水平。此外，虽然半月板损伤 ACL 丢失后更常见，其在病理生理学中的作用 ACL 断裂后的骨关节病尚不清楚。 我们假设膝关节动态不稳定性的程度 ACL 损失因人而异，并且与 随后半月板损伤的程度和发展 骨关节病。 使用 ACL 横断的犬模型，事件的时间历史记录 遵循 ACL 丢失将被记录以定义之间的关系 动态膝关节不稳定、半月板破裂和骨关节病。膝盖 动态不稳定性将在步态过程中通过三维评估 基于独特的高速双平面数字摄影测量分析 放射线照相系统。将确定关节和半月板的变化 与核磁共振成像。将对 25 只狗每只进行运动学和 MRI 测试 ACL 横断术之前和之后连续两年进行。 该项目的目标是阐明改变的重要性 ACL 后膝关节骨关节发展的力学 损失。这些发现应该具有重大的临床意义 ACL 损伤后个人适当护理的选择， 为何时进行手术干预创造合理的预测基础。