SALTED FISH & NASOPHARYNGEAL CARCINOMA

这项建议的总体目标是澄清 儿童盐渍暴露的病因学关系 FISH与鼻咽癌AS的发生发展 流行病学和动物数据表明。一项病例对照研究 中国南部潮州和客家人的鼻咽癌发病率为 建议。目标如下：(1)及早建立 接触中国咸鱼是鼻咽癌的主要危险因素 在这些中等风险人群中，他们较低的风险 相对于广东话来说，是因为他们的水平较低 暴露，(2)在不同的情况下获得更好的日常消耗量 时间段，(3)检查是否过去接触咸鱼 儿童早期患鼻咽癌的风险增加， (4)研究盐分摄入之间的相互作用(如果有的话) 鱼和膳食中的微量营养素，如维生素C和A 鼻咽癌的发病机制。汕头地区(人口为潮人) 约300名年轻(40岁以下)鼻咽癌病例的母亲 而年龄和性别匹配的母亲将 关于童年学习环境的采访 研究对象。在眉县(人口为客家人)，母亲 约200例年轻(40岁以下)鼻咽癌病例和三个孩子的母亲 年龄和性别相匹配的对照组的年龄和性别也会相似 采访过了。 中国咸鱼被证明会导致细菌突变 (鼠伤寒沙门氏菌)与哺乳动物的形态转化 细胞(C3H10T1/2小鼠胚胎细胞)。有人建议，这些 使用两种生物检测方法来指导分离和 黄曲霉中致癌物质S的鉴定 中国咸鱼。最终，慢性整体动物实验 将使用高度提纯或合成的材料进行 确认可疑化合物的致癌性。

The overall objective of this proposal is to elucidate the etiologic relationship between childhood exposure to Chinese salted fish and the development of nasopharyngeal carcinoma (NPC) as suggested by epidemiologic and animal data. A case-control study of NPC in the Chiu Chau and Hakka populations of southern China is proposed. The goals are as follows: (1) to establish that early exposure to Chinese salted fish is a major risk factor for NPC among these intermediate risk populations and that their lower risk relative to the Cantonese is a result of their lower level of exposure, (2) to better quantity of usual consumption at various time periods, (3) to examine whether exposure to salted fish past early childhood is associated with an increased risk of NPC, and (4) to examine the interaction, if any, between intake of salted fish and dietary micronutrients such as vitamins C and A in the pathogenesis of NPC. In Shantou Prefecture (population is Chiu Chau), mothers of about 300 young (under age 40 years) NPC cases and mothers of an equal number of age and sex matched controls will be interviewed regarding the childhood environment of study subjects. In Meixian Prefecture (population is Hakka), mothers of about 200 young (under age 40 years) NPC cases and mothers of three times as many age and sex matched controls will be similarly interviewed. Chinese salted fish has been shown to cause mutation in bacteria (S. typhimurium) and morphological transformation in mammalian cells (C3H10T1/2 mouse embryo cells). It is proposed that these two bioassays be employed to guide the isolation and characterization of the carcinogenic compound(s) contained in Chinese salted fish. Ultimately, chronic whole animal experiments using highly purified or synthetic material will be conducted to confirm the carcinogenicity of suspected compounds.