SALTED FISH & NASOPHARYNGEAL CARCINOMA

咸鱼

• 批准号: 2090227
• 负责人: JOSEPH R LANDOLPH
• 金额: $ 30.42万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2090227
• 关键词: Chinese; Salmonella typhimurium; alternatives to animals in research; ascorbate; bacterial genetics; cancer information system; cancer risk; carcinoma; developmental nutrition; environment related neoplasm /cancer; fish; food resource; histopathology; human subject; interview; mutagens; nasopharyngeal neoplasms; neoplasm /cancer genetics; nutrition aspect of cancer; nutrition related neoplasm /cancer; nutrition related tag; questionnaires; retinoids

The overall objective of this proposal is to elucidate the etiologic relationship between childhood exposure to Chinese salted fish and the development of nasopharyngeal carcinoma (NPC) as suggested by epidemiologic and animal data. A case-control study of NPC in the Chiu Chau and Hakka populations of southern China is proposed. The goals are as follows: (1) to establish that early exposure to Chinese salted fish is a major risk factor for NPC among these intermediate risk populations and that their lower risk relative to the Cantonese is a result of their lower level of exposure, (2) to better quantity of usual consumption at various time periods, (3) to examine whether exposure to salted fish past early childhood is associated with an increased risk of NPC, and (4) to examine the interaction, if any, between intake of salted fish and dietary micronutrients such as vitamins C and A in the pathogenesis of NPC. In Shantou Prefecture (population is Chiu Chau), mothers of about 300 young (under age 40 years) NPC cases and mothers of an equal number of age and sex matched controls will be interviewed regarding the childhood environment of study subjects. In Meixian Prefecture (population is Hakka), mothers of about 200 young (under age 40 years) NPC cases and mothers of three times as many age and sex matched controls will be similarly interviewed. Chinese salted fish has been shown to cause mutation in bacteria (S. typhimurium) and morphological transformation in mammalian cells (C3H10T1/2 mouse embryo cells). It is proposed that these two bioassays be employed to guide the isolation and characterization of the carcinogenic compound(s) contained in Chinese salted fish. Ultimately, chronic whole animal experiments using highly purified or synthetic material will be conducted to confirm the carcinogenicity of suspected compounds.

本提案的总体目标是阐明 儿童期接触中国盐的病因学关系 鱼类与鼻咽癌的发展， 流行病学和动物数据表明。 病例对照研究 华南地区潮州和客家人的NPC比例是 提出了 目标如下：（1）尽早建立 接触中国咸鱼是患鼻咽癌的主要危险因素 在这些中等风险人群中， 相对于广东人来说， （2）在各种不同的情况下，获得更好的日常消费量 时间段，（3）检查是否暴露于咸鱼过去 儿童早期与NPC风险增加有关， (4)如果有相互作用的话， 鱼和膳食微量营养素，如维生素C和A， 鼻咽癌的发病机制。 在汕头地区（人口为100万）， 周），约300名年轻（40岁以下）NPC病例的母亲 同样数量的年龄和性别匹配的对照组的母亲将 就童年学习环境接受采访 科目 在梅县（人口为客家人）， 约200名年轻（40岁以下）NPC病例和3名 年龄和性别相匹配的对照组的数量将是 受访 中国咸鱼已被证明会导致细菌突变 （S.鼠伤寒沙门氏菌）和哺乳动物的形态转化 细胞（C3H10T1/2小鼠胚胎细胞）。 建议这些 采用两种生物测定来指导分离， 中所含致癌化合物的表征 中国咸鱼。 最终，慢性整体动物实验 使用高度纯化或合成的材料， 确认可疑化合物的致癌性。

项目成果

Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China.

• 发表时间: 1988-04
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Mimi C. Yu;C. Mo;Wei-Xiong Chong;F. Yeh;B. E. Henderson

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.

• 发表时间: 1993-03
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: C. Spruck;W. Rideout;A. Olumi;P. F. Ohneseit;A. Yang;Y. Tsai;P. Nichols;T. Horn;G. Hermann;K. Steven

Induction of malignant nasal cavity tumours in Wistar rats fed Chinese salted fish.

• DOI: 10.1038/bjc.1989.250
• 发表时间: 1989-08
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Yu, M C;Nichols, P W;Zou, X N;Estes, J;Henderson, B E
• 通讯作者: Henderson, B E

Diet and nasopharyngeal carcinoma.

• DOI: 10.1016/0378-1097(90)90614-v
• 发表时间: 1990
• 期刊: Progress in clinical and biological research
• 作者: MimiC. Yu

Absence of p53 gene mutations in primary nasopharyngeal carcinomas.

• 发表时间: 1992-09
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Charles H. Spruck;Y. Tsai;D. Huang;Allen S. Yang;William M. Rideout;M. Gonzalez‐Zulueta;Peter S. Choi;K. Lo;Mimi C. Yu;Peter A. Jones