NMR IMAGING AND SPECTROSCOPY OF SILICONE BREAST IMPLANTS

硅胶乳房植入物的核磁共振成像和光谱学

• 批准号: 2100228
• 负责人: LEONCIO GARRIDO
• 金额: $ 28.38万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2100228
• 关键词: biomaterial compatibility; biomedical equipment development; breast surgery; chemical structure; human subject; laboratory rat; liver; lymph nodes; mammography; nuclear magnetic resonance spectroscopy; prosthesis; reproductive system disorder diagnosis; sign /symptom; technology /technique; technology /technique development; ultrasonography; women's health

The overall goal of this research is to develop and apply NMR techniques to assess silicone gel-filled breast implants for biocompatibility, rupture and spread of silicone to distant sites. The growing concern over silicone implants, a serious women's health issue, makes this research clinically relevant. In this proposal, both NMR spectroscopy and MR imaging will be evaluated. Spectroscopy will be used to asses the rupture of silicone implants. In the proposed research, techniques will be optimized for NMR spectroscopy of silicone.. To determine silicone biocompatibility, in vitro multinuclear (1H, 13C, and 29 si) NMR chemical shift information will be obtained from silicones injected in animal tissue, surgically removed silicone gel-filled breast implants, and related tissue from patients. Similarly, in vivo localized NMR spectroscopy (1H,29Si) will be optimized for patient studies. The spectroscopic assessment of silicone distribution will be correlated with histopathology. The proposed research will also optimize and apply chemical shift imaging sequences to assess the NMR characterization of implants and the spatial distribution of silicone. MR images will be compared with mammography and ultrasonography to determine the presence of implant rupture. These results will be confirmed by surgical findings, whenever these are available. Finally a pilot clinical study will be performed in a group of patients to determine if the presence of silicone at distant sites is associated with patient symptomatology. It is anticipated that the techniques developed through this research will have widespread application in women with silicone gel-filled breast prostheses.

本研究的总体目标是发展和应用核磁共振技术 为了评估硅凝胶填充的乳房植入物的生物相容性， 硅胶破裂并扩散到远处。 的日益关注 硅胶植入物，一个严重的妇女健康问题，使这一点， 临床相关研究。 在这个提议中，NMR光谱学 并对MR成像进行评价。 光谱学将用于评估 硅胶植入物破裂。 在拟议的研究中，将优化NMR技术 硅树脂的光谱学 为了确定硅胶的生物相容性， 体外多核（1H、13 C和29 Si）NMR化学位移信息 将通过外科手术从动物组织中注射的硅胶中获得 取出硅胶填充乳房植入体和相关组织， 患者 类似地，体内局部NMR光谱（1H，29Si）将 为患者研究进行优化。 光谱评估 硅胶分布将与组织病理学相关。 的 拟议的研究还将优化和应用化学位移成像 序列，以评估植入物的NMR表征和空间 硅胶的分布 将MR图像与乳腺X线摄影进行比较 和超声波检查以确定植入物是否破裂。 这些 结果将通过手术结果证实，无论何时， available. 最后，将在一组患者中进行初步临床研究， 以确定远端部位存在硅胶是否与 病人的身体状况 预计这些技术 通过这项研究开发的将广泛应用于妇女 填充硅胶的乳房假体