NMR IMAGING AND SPECTROSCOPY OF SILICONE BREAST IMPLANTS

硅胶乳房植入物的核磁共振成像和光谱学

• 批准号: 2100229
• 负责人: LEONCIO GARRIDO
• 金额: $ 26.66万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2100229
• 关键词: biomaterial compatibility; biomedical equipment development; breast surgery; chemical structure; human subject; laboratory rat; liver; lymph nodes; mammography; nuclear magnetic resonance spectroscopy; prosthesis; reproductive system disorder diagnosis; sign /symptom; technology /technique; technology /technique development; ultrasonography; women's health

The overall goal of this research is to develop and apply NMR techniques to assess silicone gel-filled breast implants for biocompatibility, rupture and spread of silicone to distant sites. The growing concern over silicone implants, a serious women's health issue, makes this research clinically relevant. In this proposal, both NMR spectroscopy and MR imaging will be evaluated. Spectroscopy will be used to asses the rupture of silicone implants. In the proposed research, techniques will be optimized for NMR spectroscopy of silicone.. To determine silicone biocompatibility, in vitro multinuclear (1H, 13C, and 29 si) NMR chemical shift information will be obtained from silicones injected in animal tissue, surgically removed silicone gel-filled breast implants, and related tissue from patients. Similarly, in vivo localized NMR spectroscopy (1H,29Si) will be optimized for patient studies. The spectroscopic assessment of silicone distribution will be correlated with histopathology. The proposed research will also optimize and apply chemical shift imaging sequences to assess the NMR characterization of implants and the spatial distribution of silicone. MR images will be compared with mammography and ultrasonography to determine the presence of implant rupture. These results will be confirmed by surgical findings, whenever these are available. Finally a pilot clinical study will be performed in a group of patients to determine if the presence of silicone at distant sites is associated with patient symptomatology. It is anticipated that the techniques developed through this research will have widespread application in women with silicone gel-filled breast prostheses.

本研究的总体目标是开发和应用核磁共振技术 为了评估填充硅胶的乳房植入物的生物相容性， 硅胶破裂并扩散到远处。日益增长的担忧 硅胶植入物，一个严重的女性健康问题，使这一点 与临床相关的研究。在这项提议中，核磁共振光谱学 并对磁共振成像进行评估。光谱学将被用于评估 硅胶植入物破裂。 在拟议的研究中，核磁共振技术将得到优化 有机硅的光谱学..为了确定硅胶的生物相容性，在 体外多核(~1H、~(13)C和~(29)Si)核磁共振化学位移信息 将通过外科手术从动物组织中注射的有机硅中获得 取出填充硅胶的乳房植入物和相关组织 病人。类似地，体内定域核磁共振波谱(1H，29Si)将 针对患者研究进行优化。光谱学评价 硅胶的分布将与组织病理学相关。这个 拟议的研究还将优化和应用化学位移成像 用于评估植入物和空间的核磁共振表征的序列 硅胶的分布。磁共振图像将与乳房X光照相比较 并进行超声检查，以确定是否存在种植体破裂。这些 无论何时，手术结果都将得到证实。 可用。 最后，将在一组患者中进行先导性临床研究 以确定在遥远地点的硅胶的存在是否与 从病人的症状来看。据预计，这些技术 通过这项研究开发的产品将在女性中得到广泛应用 用硅胶填充的乳房假体。