NMR IMAGING AND SPECTROSCOPY OF SILICONE BREAST IMPLANTS

硅胶乳房植入物的核磁共振成像和光谱学

• 批准号: 2330834
• 负责人: LEONCIO GARRIDO
• 金额: $ 26.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1998-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2330834
• 关键词: biomaterial compatibility; biomedical equipment development; breast implants; breast surgery; chemical structure; human subject; laboratory rat; liver; lymph nodes; mammography; nuclear magnetic resonance spectroscopy; reproductive system disorder diagnosis; sign /symptom; technology /technique; technology /technique development; ultrasonography; women's health

The overall goal of this research is to develop and apply NMR techniques to assess silicone gel-filled breast implants for biocompatibility, rupture and spread of silicone to distant sites. The growing concern over silicone implants, a serious women's health issue, makes this research clinically relevant. In this proposal, both NMR spectroscopy and MR imaging will be evaluated. Spectroscopy will be used to asses the rupture of silicone implants. In the proposed research, techniques will be optimized for NMR spectroscopy of silicone.. To determine silicone biocompatibility, in vitro multinuclear (1H, 13C, and 29 si) NMR chemical shift information will be obtained from silicones injected in animal tissue, surgically removed silicone gel-filled breast implants, and related tissue from patients. Similarly, in vivo localized NMR spectroscopy (1H,29Si) will be optimized for patient studies. The spectroscopic assessment of silicone distribution will be correlated with histopathology. The proposed research will also optimize and apply chemical shift imaging sequences to assess the NMR characterization of implants and the spatial distribution of silicone. MR images will be compared with mammography and ultrasonography to determine the presence of implant rupture. These results will be confirmed by surgical findings, whenever these are available. Finally a pilot clinical study will be performed in a group of patients to determine if the presence of silicone at distant sites is associated with patient symptomatology. It is anticipated that the techniques developed through this research will have widespread application in women with silicone gel-filled breast prostheses.

本研究的总体目标是开发和应用核磁共振技术 评估硅胶填充乳房植入物的生物相容性， 硅胶破裂并扩散到远处。 日益增长的关注 硅胶植入物是一个严重的女性健康问题，这使得 研究临床相关。 在该提案中，核磁共振波谱 并对 MR 成像进行评估。 光谱学将用于评估 硅胶植入物破裂。 在拟议的研究中，将对核磁共振技术进行优化 有机硅的光谱学..为了确定有机硅的生物相容性， 体外多核（1H、13C 和 29 si）NMR 化学位移信息 将通过手术将有机硅注射到动物组织中获得 取出硅胶填充的乳房植入物和相关组织 患者。 类似地，体内局部核磁共振波谱 (1H,29Si) 将 针对患者研究进行优化。 光谱评估 有机硅的分布与组织病理学相关。 这 拟议的研究还将优化和应用化学位移成像 序列来评估植入物的 NMR 表征和空间 有机硅的分布。 MR 图像将与乳房 X 光检查进行比较 和超声检查以确定是否存在种植体破裂。 这些 结果将由手术结果证实，无论何时 可用的。 最后将在一组患者中进行试点临床研究 确定远处部位存在硅酮是否相关 与患者的症状。 预计该技术 通过这项研究开发的产品将广泛应用于女性 使用硅胶填充的乳房假体。

项目成果

Biodegradation of polysiloxanes in lymph nodes of rats measured with 29Si NMR.

• DOI: 10.1016/s0142-9612(98)00208-7
• 发表时间: 1999-03
• 期刊: Biomaterials
• 影响因子: 14
• 作者: B. Pfleiderer;A. Moore;E. Tokareva;J. Ackerman;L. Garrido

Silicone gel-filled breast implants in women: findings at H-1 MR spectroscopy.

女性硅胶填充乳房植入物：H-1 磁共振波谱的发现。

• DOI: 10.1148/radiology.201.3.8939231
• 发表时间: 1996
• 期刊: Radiology.
• 作者: Pfleiderer,B;Campbell,T;Hulka,CA;Kopans,DB;Lean,CL;Ackerman,JL;Brady,TJ;Garrido,L
• 通讯作者: Garrido,L