SURFACE MODIFYING TO IMPROVE URINARY CATHETER FUNCTION

描述：(改编自申请人的摘要)目前使用 导尿管插入时会产生疼痛，损伤尿路组织， 并导致较高的细菌感染率。在第一阶段，获得专利 采用BSI光化学法在导尿管表面涂覆高密度涂层。 润滑性涂层，摩擦系数降低10倍 橡胶乳胶导尿管和硅橡胶导尿管的5倍。这个 相同的涂层可使葡萄球菌的粘附率降低85%-95% 表皮肌。此外，将氟喹诺酮类抗生素加入到 涂层导尿管产生的缓释抗生素活性是 体外有效期为12天。在第二阶段，涂装程序 装有润滑剂的导管将得到优化，以(1)最大限度地 润滑性和耐用性，以及(2)最大限度地减少细菌定植和 结垢的沉积。将制定程序以涂上 导尿管管腔。最后，将对涂层导管进行评估。 在体外和体内都具有细胞毒性和减少细菌粘附性 活着。

DESCRIPTION: (Adapted from the applicant's abstract) Currently used urinary catheters produce pain upon insertion, injure urethral tissue, and cause high rates of bacterial infections. During Phase I, patented BSI photochemistry was used to coat urinary catheters with highly lubricous coatings, which reduced the coefficient of friction 10-fold on rubber latex catheters and 5- fold on silicone rubber catheters. The same coatings produced 85-95% reductions in adherence by Staphylococcus epidermidis. Also, incorporation of a fluoroquinolone antibiotic into the coated catheters produced slow-release antibiotic activity that was effective for 12 days in vitro. During Phase II, procedures for coating catheters with lubricous agents will be optimized to (1) maximize lubricity and durability and (2) minimize bacterial colonization and deposition of incrustations. Procedures will be developed to coat the lumens of urinary catheters. Finally, coated catheters will be evaluated for cytotoxicity and reduced bacterial adherence both in vitro and in vivo.