SURFACE MODIFICATION FOR INFECTION-RESISTANT BIOMATERIAL

抗感染生物材料的表面改性

• 批准号: 3489334
• 负责人: LISE W DURAN
• 金额: $ 5万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3489334
• 关键词: antibiotics; biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biomedical equipment development; contact lens; high performance liquid chromatography; photoactivation; polymers

Infections are the most serious complication of medical devices. High incidence of infection is associated with all devices, including contact lenses, catheters, dialysis materials and cardiovascular implants. Infections are treated as they occur, but prevention is the most promising approach to decreasing these problems. One likely method for reducing device-related infections is to bond a coating to the material which will repel microbial attachment and colonization. We have preliminary results showing that covalently coupled coatings reduce bacterial colonization of polystyrene. In this Phase I effort, we propose to immobilize these coatings to contact lens materials and investigate the ability of these coatings to reduce microbial adherence and proliferation. We will also study the ability of these hydrogel coatings to act as antibiotic, slow-release drug delivery vehicles. The anticipated results from this Phase I project will demonstrate that photochemical surface-modification win repel microbial attachment to contact lens materials. During Phase U, we will optimize coating chemistries and expand the testing to animal models.

感染是医疗器械最严重的并发症。高 感染发生率与所有器械相关，包括接触 镜片、导管、透析材料和心血管植入物。 感染在发生时就得到治疗，但预防是最有希望的 减少这些问题的方法。一种可能的方法是减少 与器械相关的感染是将涂层粘合到材料上， 排斥微生物附着和定植。 我们有初步的结果表明，共价耦合涂层减少， 聚苯乙烯的细菌定植。在第一阶段，我们建议 为了将这些涂层涂覆到接触透镜材料上， 这些涂层减少微生物粘附和增殖的能力。 我们还将研究这些水凝胶涂层的能力， 抗生素缓释药物载体预期的结果 从这个第一阶段项目将证明， 表面改性隐形眼镜排斥微生物附着于接触透镜 材料.在U阶段，我们将优化涂层化学， 动物模型试验。

项目成果

Photochemical coatings for the prevention of bacterial colonization.

用于防止细菌定植的光化学涂层。

• DOI: 10.1177/088532829100600203
• 发表时间: 1991
• 期刊: Journal of biomaterials applications
• 影响因子: 2.9
• 作者: Dunkirk,SG;Gregg,SL;Duran,LW;Monfils,JD;Haapala,JE;Marcy,JA;Clapper,DL;Amos,RA;Guire,PE
• 通讯作者: Guire,PE