MICROBICIDAL COATINGS FOR DENTAL UNIT WATERLINES

牙科综合治疗机水管杀菌涂层

• 批准号: 2800671
• 负责人: LISE W DURAN
• 金额: $ 10万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2002-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2800671
• 关键词: antiinfective agents; antiseptic sterilization; chemical synthesis; molecular film; phosphorus compounds; quaternary ammonium compound; surface coating; technology /technique development; water microbiology; water supply; water treatment

There is increasing recognition that biofilm formation has a significant impact on dental unit waterlines. Bacteria from the main water source to dental clinics or from previous patient's oral flora adhere to the luminal walls of the waterlines and become a dense accumulation of biofilm over a period of weeks or months. The goal of this project is to develop an antimicrobial surface coating for dental unit waterlines using BSI's proprietary photoimmobilization technology. This project will employ alkyl quiaternary ammonium and phasphonium groups as the microbicidal agent. Fluoroalkyl groups will be used to reduce biofouling. The Phase I objectives are to synthesize alkyl quaternary ammonium and phosphonium coating reagents with and without fluoroalkyl groups; demonstrate microbicidal activity of the photoalkyl quat reagents; immobilize the coating reagents on dental waterline substrates; examine the efficacy of the modified materials in reducing bacterial adherence and colonization; evaluate bacterial biofilm development and accumulation on modified materials using reactor systems; determine whether modified materials are toxic in vitro; and demonstrate stability of microbicidal and antifouling coatings against liquid wash and wet/dry cycle forces. The long-range goal of this project is to develop durable, self-sterilizing, and antifouling films on waterline surfaces. PROPOSED COMMERCIAL APPLICATION: Microbial colonization and biofilm formation remains a major cost, human health, and product quality problem for dental and pharmaceutical industries, health care and public lodging, and marine vessel and stationary structure industries. Successful use of BSI's coating technology with microbicidal and antifouling coating polymers will significantly improve our ability to maintain microbial quality of surfaces.

越来越多的人认识到生物膜的形成对牙单位水线有重大影响。从主要水源到牙科诊所或以前病人口腔菌群的细菌附着在水线的管腔壁上，并在数周或数月的时间内形成密集的生物膜堆积。该项目的目标是利用BSI专有的光固定技术开发牙科单元水线的抗菌表面涂层。本项目将采用烷基季铵盐和磷基作为杀菌剂。氟烷基将用于减少生物污染。第一阶段的目标是合成含和不含氟烷基的烷基季铵盐和磷包衣试剂；证明了光烷基四元试剂的杀微生物活性；将涂布试剂固定在牙科水线基板上；检查改性材料在减少细菌粘附和定植方面的功效；利用反应器系统评价改性材料上细菌生物膜的发育和积累；确定改性材料在体外是否有毒；并证明了杀微生物和防污涂层对液体洗涤和湿/干循环力的稳定性。该项目的长期目标是在水线表面开发耐用，自消毒和防污的薄膜。建议的商业应用：微生物定植和生物膜形成仍然是牙科和制药行业、医疗保健和公共住宿、海洋船舶和固定结构行业的主要成本、人类健康和产品质量问题。BSI的涂层技术与杀微生物和防污涂层聚合物的成功应用将显著提高我们保持表面微生物质量的能力。