ASP--A HIGH RESOLUTION TOMOGRAPH FOR SMALL ANIMALS

这项研究的长期目标是开发仪器和 放射性同位素定位体内定量技术的研究进展 为了加速和简化小动物的设计和 新放射性药物的评价。 动物冲刺(ASP)是一种高分辨率的单光子环状断层扫描仪 仿照Sprint，但专门为99mTc、123I、 和131I在小鼠和大鼠体内的毫米分辨率。它也有能力 以较低的分辨率成像较大的动物，如灵长类动物和狗。 在这项提案中要求提供支持，以完成 ASP，为表征仪器性能，进行验证测试 使用幻影，并将断层摄影术同化为我们的日常使用 放射性药物生物分配实验室。 该仪器还将用于另一个研究项目，以 验证现在的图像重建和估计算法 使用幻影和小动物进行开发。

The long-term aim of this research is to develop instrumentation and techniques for quantification in vivo of radioisotope localization in small animals in order to accelerate and simplify the design and evaluation of new radiopharmaceuticals. Animal SPRINT (ASP) is a high-resolution single-photon ring tomograph modeled after SPRINT but specifically designed for imaging 99mTc, 123I, and 131I in mice and rats with millimeter resolution. It is also capable of imaging larger animals such as primates and dogs at reduced resolution. Support is requested in this proposal to complete the final assembly of ASP, to characterize instrument performance, carry out verification tests with phantoms, and to assimilate the tomograph into routine use in our radiopharmaceutical biodistribution laboratory. This instrument will also be used in a separate research project to validate image reconstruction and estimation algorithms now under development using phantoms and small animals.