RADIONUCLIDES: RADIATION DETECTION AND QUANTIFICATION

这项拟议工作的长期目标是优化性能， SPRINT II的功能，目的是能够更好地研究 静态和动态过程定量。 目的是扩大 SPECT的功能成像。 要做到这一点， 提高了固有检测器的分辨率和线性度， 孔径几何结构，更精确的图像重建算法，以及 更好地了解信息传递的性质， 层析成像过程。 探测器的改进将通过蒙特卡罗建模来完成 并且通过扩展一维最大似然位置估计 到二维。 最佳孔径设计将包括对互信息的研究， 分析重建图像的方差和偏差。 有效的重建算法将开发的非标准 SPRINT II的采样几何结构，包括衰减和散射 纠正一下 最后，将互信息的应用扩展到 检测和识别任务。

The long term goal of this proposed work is to optimize the performance and functionality of SPRINT II with the aim of being better able to study both static and dynamic processes quantitatively. The aim is to extend the capabilities of SPECT to functional imaging. To accomplish this requires improvements in intrinsic detector resolution and linearity, refinement in aperture geometry, more accurate image reconstruction algorithms, and a better understanding of the nature of information transfer in the tomographic imaging process. Detector improvements will be accomplished by means of Monte Carlo modeling and by extending the 1-dimensional maximum likelihood position estimation to 2-dimensions. Optimum aperture design will include a study of mutual information and analysis of variance and bias in reconstructed images. Efficient reconstruction algorithms will be developed for the non-standard sampling geometry of SPRINT II which will include attenuation and scatter correction. Finally, application of mutual information will be extended to detection and discrimination tasks.