ASP--A HIGH RESOLUTION TOMOGRAPH FOR SMALL ANIMALS

这项研究的长期目标是开发仪器， 体内放射性同位素定位的定量技术 为了加速和简化设计， 新放射性药物的评价。 Animal SPRINT（ASP）是一种高分辨率单光子环形断层扫描仪， 在SPRINT之后建模，但专门设计用于成像99mTc，123I， 和131 I的实验结果。它还能够 对灵长类动物和狗等大型动物进行成像时， 本提议要求提供支助，以完成 ASP，表征仪器性能，执行验证测试 与幻影，并吸收到日常使用的断层扫描仪在我们的 放射性药物生物分布实验室 该仪器还将用于一个单独的研究项目， 验证图像重建和估计算法， 使用幻影和小动物的发展。

The long-term aim of this research is to develop instrumentation and techniques for quantification in vivo of radioisotope localization in small animals in order to accelerate and simplify the design and evaluation of new radiopharmaceuticals. Animal SPRINT (ASP) is a high-resolution single-photon ring tomograph modeled after SPRINT but specifically designed for imaging 99mTc, 123I, and 131I in mice and rats with millimeter resolution. It is also capable of imaging larger animals such as primates and dogs at reduced resolution. Support is requested in this proposal to complete the final assembly of ASP, to characterize instrument performance, carry out verification tests with phantoms, and to assimilate the tomograph into routine use in our radiopharmaceutical biodistribution laboratory. This instrument will also be used in a separate research project to validate image reconstruction and estimation algorithms now under development using phantoms and small animals.