RADIONUCLIDES--RADIATION DETECTION AND QUANTIFICATION

描述：(改编自应用程序)这项工作的长期目标 研究是为了开发方法和仪器以获得改进 放射性同位素在人和动物体内分布的量化。 Sprint II是第三代SPECT仪器，作为 持续的努力。本提案的重点是定义和验证 SPECT数据的采集、校正和分析方法 将促进该仪器的临床和实验使用，并 利用它的一些独特功能。申请者将调查两个 Sprint II的创新数据获取战略，它应该 显著提高数据准确性并改善信噪比：1) 确定获取大脑顶点视图的价值 常规SPECT采集并将此信息合并到 图像重建或参数估计过程；2)确定 最佳孔径分辨率以最佳估计心肌速率常数 可自由扩散的示踪剂，如SQ30217。分析将包括 非侵入性确定输入功能、门控效果和 狭缝宽度的时间变化。申请者还将发展和 评估测量和校正散射、衰减和 耐心动议，并为此对Sprint II进行硬件改进 提高空间和能量分辨率。

DESCRIPTION: (Adapted from the application) The long term goal of this research is to develop methods and instrumentation to obtain improved quantification of the radioisotope distribution in humans and animals. SPRINT II is a third generation SPECT instrument developed as part of this ongoing effort. The focus of this proposal is to define and validate methods of data acquisition, correction, and analysis of SPECT data which will facilitate clinical and experimental use of this instrument and exploit some of its unique features. The applicants will investigate two innovative data acquisition strategies with SPRINT II, which should measurably increase data accuracy and improve signal-to-noise ratios: 1) determine the value of acquiring a vertex view of the brain during a conventional SPECT acquisition and incorporating this information into the image reconstruction or parameter estimation process; 2) determine the optimal aperture resolution to best estimate myocardial rate constants for freely diffusible tracers such as SQ30217. The analysis will include noninvasive determination of the input function, the effects of gating, and temporal variation of the slit width. The applicants will also develop and evaluate methods to measure and correct for scatter, attenuation, and patient motion and make hardware improvements to SPRINT II for the purpose of improving both spatial and energy resolution.