Organic Linchpin Reagents to Construct Structural Diversity and Complexity

构建结构多样性和复杂性的有机关键试剂

• 批准号: DP200100063
• 负责人: A/Prof Thanh Vinh Nguyen
• 金额: $ 29.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100063
• 关键词: Organic; Linchpin; Reagents; Construct; Structural

High-energy chemical species such as carbenes, nitrenes or free radicals are often used as reactive intermediates in organic reactions to rapidly generate new bonds, structures and structural complexities. Due to their reactive nature, traditionally only one type of high-energy chemical species can be featured at a time to avoid unwanted complicated side reactions. This project aims to develop novel synthetic substrates bearing multiple carbene and nitrene precursors of different types. These high-energy intermediates can be released in a relayed fashion by controlling orthogonal stimuli and therefore acting as linchpin reagents for quick construction of bio- or photo-active compounds and unprecedented complicated structures.

高能化学物质如卡宾、氮烯或自由基通常用作有机反应中的活性中间体，以快速产生新的键、结构和结构复杂性。由于它们的反应性质，传统上一次只能使用一种类型的高能化学物质，以避免不必要的复杂副反应。该项目旨在开发具有多种不同类型的卡宾和氮烯前体的新型合成底物。这些高能中间体可以通过控制正交刺激以中继方式释放，因此可以作为快速构建生物或光活性化合物和前所未有的复杂结构的关键试剂。