ADAPTIVE REGULATION OF NUTRIENT TRANSPORT OF THE GUT

肠道营养运输的适应性调节

• 批准号: 2169295
• 负责人: JARED M DIAMOND
• 金额: $ 33.38万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2169295
• 关键词: Anura; alternatives to animals in research; aminoacid metabolism; aminoacid transport; apical membrane; bioenergetics; caloric dietary content; chickens; dietary aminoacid; dietary proteins; fish; gastrointestinal epithelium; gastrointestinal hormones; gastrointestinal nutrient absorption; ion transport; juvenile animal; laboratory mouse; laboratory rabbit; laboratory rat; malnutrition; mature animal; membrane permeability; membrane transport proteins; mother /embryo /fetus nutrition; nitrogen metabolism; nonelectrolyte transport; nutrition related tag; potassium; sodium

This project lies at the interface between nutrition and gastroenterology. It asks how the nutrient uptake mechanisms of the intestine are adaptively regulated. The objectives focus on three questions. 1. What are the patterns of changes in nutrient uptake with diet changes, pregnancy, and other normal and disease-related conditions? 2. What are the mechanisms responsible for these changes? 3. What are the signals for these changes? The specific aims are four-fold: 1. What dietary conditions yield maximal induction of each of the four main Na+-dependent amino acid transporters? This study will guide attempts to isolate transporters and to understand inducing signals. 2. Does substrate-dependent induction of transporters take place only in differentiating crypt cells, or in mature enterocytes as well? 3. What are the patterns, triggering signals, functional significance, mechanisms, and possible role as digestive bottlenecks, for the changes in transporters during ontogenetic development? 4. By what mechanisms does experimental diabetes alter nutrient absorption by the intestine? The main methods to be used measure tracer uptake, intestinal morphometry, and transporter site number. The project has health-related implications for: 1. the dietary role of amino acids, not only as essential nutrients but also as inducers of absorption of other nutrients; 2. health consequences of altered plasma levels of nutrients due to altered intestinal nutrient uptake; 3. altered nutrient uptake in diabetes and other disease states.

这个项目位于营养学和胃肠病学的交汇处。