ENTEROGLUCAGON AND INTESTINAL ADAPTATION

肠胰高血糖素和肠道适应

基本信息

  • 批准号:
    3244206
  • 负责人:
  • 金额:
    $ 22.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1990
  • 资助国家:
    美国
  • 起止时间:
    1990-09-01 至 1993-08-31
  • 项目状态:
    已结题

项目摘要

This project's objective is to identify the role of enteroglucagon as a humoral mediator of intestinal adaptation. The intestine has long been known to exhibit two distinct types of adaptation. First, intestinal mucosal mass increases, and hence absorption of all nutrients increases, under many conditions associated with increased energy needs leading to hyperphagia. Second, specific intestinal transporters are up- or down-regulated by changes in dietary levels or body stores of their substrates. Strongly suggestive but not conclusive evidence makes it likely that enteroglucagon is a (the?) humoral mediator of the former response, and may also contribute to the latter response in the case of dietary carbohydrate effects on intestinal glucose transporters. Hence this project will test enteroglucagon's role in adaptation by means of in vivo studies in rats, employing critical tests that could not be carried out until recently because of lack of knowledge of endogenous enteroglucagon forms, their limited availability for in-vivo testing, and inadequate assays. One approach will be to test the effects of chronic infusions of two enteroglucagon peptides, oxyntomodulin and GLP-1 7-36 amide, on mucosal growth and on intestinal nutrient uptake. The other approach will be to test the effect of immunoneutralizing enteroglucagon on both types of adaptation in two rat models that this laboratory developed. One of the models produces a several-fold increase in mucosal mass, the other a two-fold increase in glucose transporter activity. The health relatedness of this project derives from the role of intestinal adaptation in important clinical conditions, such as diabetes, short bowel syndrome, pregnancy, lactation, and exercise.
本项目的目的是确定肠胰高血糖素的作用

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JARED M DIAMOND其他文献

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{{ truncateString('JARED M DIAMOND', 18)}}的其他基金

MATERNAL GUT/MAMMARY GLAND INTERFACE IN LACTATION
哺乳期母体肠道/乳腺界面
  • 批准号:
    2025471
  • 财政年份:
    1993
  • 资助金额:
    $ 22.79万
  • 项目类别:
MATERNAL GUT/MAMMARY GLAND INTERFACE IN LACTATION
哺乳期母体肠道/乳腺界面
  • 批准号:
    2203094
  • 财政年份:
    1993
  • 资助金额:
    $ 22.79万
  • 项目类别:
MATERNAL GUT/MAMMARY GLAND INTERFACE IN LACTATION
哺乳期母体肠道/乳腺界面
  • 批准号:
    3331987
  • 财政年份:
    1993
  • 资助金额:
    $ 22.79万
  • 项目类别:
MATERNAL GUT/MAMMARY GLAND INTERFACE IN LACTATION
哺乳期母体肠道/乳腺界面
  • 批准号:
    2203093
  • 财政年份:
    1993
  • 资助金额:
    $ 22.79万
  • 项目类别:
MATERNAL GUT/MAMMARY GLAND INTERFACE IN LACTATION
哺乳期母体肠道/乳腺界面
  • 批准号:
    2403321
  • 财政年份:
    1993
  • 资助金额:
    $ 22.79万
  • 项目类别:
ENTEROGLUCAGON AND INTESTINAL ADAPTATION
肠胰高血糖素和肠道适应
  • 批准号:
    3244207
  • 财政年份:
    1990
  • 资助金额:
    $ 22.79万
  • 项目类别:
ENTEROGLUCAGON AND INTESTINAL ADAPTATION
肠胰高血糖素和肠道适应
  • 批准号:
    3244205
  • 财政年份:
    1990
  • 资助金额:
    $ 22.79万
  • 项目类别:
ADAPTIVE REGULATION OF NUTRIENT TRANSPORT OF THE GUT
肠道营养运输的适应性调节
  • 批准号:
    2169295
  • 财政年份:
    1978
  • 资助金额:
    $ 22.79万
  • 项目类别:
ADAPTIVE REGULATION OF NUTRIENT TRANSPORT OF THE GUT
肠道营养运输的适应性调节
  • 批准号:
    2169294
  • 财政年份:
    1978
  • 资助金额:
    $ 22.79万
  • 项目类别:
ANIMAL MODELS OF EXTREME HYPERPHAGIA AND HIGH METABOLISM
极度暴食和高代谢的动物模型
  • 批准号:
    6384998
  • 财政年份:
    1978
  • 资助金额:
    $ 22.79万
  • 项目类别:

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膳食碳水化合物是长寿、健康生活的关键吗?
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