FLUPENTHIXOL DECANOATE IN METHAMPHETAMINE SMOKING

注射甲基苯丙胺或吸烟(“冰”)越来越多地导致 难以获得的严重兴奋剂依赖 药理和门诊心理治疗。在公开场合 在试点试验中，我们评估了一种需要黄原烯的仓库的效果 少见的肌注给药，氟苯硫醇，用于治疗 戒烟是一种非常类似的兴奋剂，可卡因。十个穷孩子 预后，门诊吸食可卡因的可卡因吸烟者接受治疗 在一项开放标签的开放式试验中使用了氟苯硫醇。氟苯硫醇 癸酸耐受性良好，并出现显著和迅速的缓解 减少渴望和使用，比之前的治疗增加260% 在这些受试者中，他们在治疗中的平均滞留时间。这 本申请提出了一项氟苯硫醇的双盲试验， 与目前针对兴奋剂滥用的口服药物疗法相比， 地塞帕明。90名甲基苯丙胺滥用者将在 随机治疗比较三种对照的临床试验 在传统心理治疗的基础上增加药物治疗：(A) 安慰剂地昔帕明联合安慰剂肌肉注射地塞米松(n=30)(B) 地昔帕明加安慰剂(30例)(C)安慰剂 地昔帕明加氟苯硫醇消炎痛肌注(n=30)。成果评估 将是全面和多维的。

Methamphetamine injection or smoking ("ice") is increasingly causing severe stimulant dependence that is refractory to available pharmacological and outpatient psychotherapeutic treatments. In an open pilot trial, we evaluated the efficacy of a depot xanthene requiring infrequent IM administration, flupenthixol decanoate, for efficacy in withdrawal from smoking the very similar stimulant, cocaine. Ten poor prognosis, outpatient "crack" cocaine smokers were administered flupenthixol decanoate in an open-label, open-ended trial. Flupenthixol decanoate was well tolerated, and appeared to markedly and rapidly decrease craving and use, producing a 260% increase over prior treatment in these subjects in their average time retained in treatment. This application proposes a double-blind flupenthixol decanoate trial with a comparison to a current oral pharmacotherapy for stimulant abuse, desipramine. Ninety methamphetamine abusers will be treated in a clinical trial with randomized treatment comparing three contrasting pharmacological treatments added to conventional psychotherapy: (a) Placebo Desipramine plus Placebo I.M. Flupenthixol Decanoate (n=30) (b) Desipramine plus Placebo I.M. Flupenthixol Decanoate (n=30) (c) Placebo Desipramine plus I.M. Flupenthixol Decanoate (n=30). Outcome assessments will be comprehensive and multidimensional.