NOVEL NEUROREGULATION OF CRACK DEPENDENCE

这项提案的目标是迅速但明确地调查 新的神经化学途径帮助抗击由 对强效可卡因的依赖。 我们建议对一种有希望的推定药物的疗效进行调查 兴奋剂滥用药物治疗，卡托普利，作为戒断促进 以及对强效可卡因依赖的复发预防治疗。 这项研究将采用安慰剂对照、双盲、随机 作业，两个单元格平行分组设计，将评估80名受试者 实验治疗24周期间，进行3次随访。 我们假设服用活性卡托普利的受试者，而不是安慰剂的受试者，将 证据：1.强效可卡因滥用严重程度降低，可操作 由于强效可卡因使用量的减少对尿液和其他物质中GCMS的定量影响 自我报告的使用量和使用频率，因为加强了对 消除对可卡因的渴望，随着戒酒和戒毒时间的延长 药物治疗中的滞留。2.提高正式和非正式文件的使用率 强效可卡因滥用12步治疗服务，已投入使用 使用自然史治疗暴露清单。3.减少 多维损害作为非药物的减少而操作 成瘾严重程度指数的维度。

The goal of this proposal is to rapidly but definitively investigate a new neurochemical avenue to help combat the decimation created by dependence on crack cocaine smoking. We propose an investigation of the efficacy of a promising putative stimulant abuse pharmacotherapy, captopril, as abstinence facilitation and relapse prevention treatment for crack cocaine dependence. The investigation will employ a placebo controlled, double-blind, random assignment, two cell parallel group design that will assess 80 subjects during 24 weeks of experimental treatment, with 3 follow-ups. We hypothesize that subjects on active captopril, but not placebo, will evidence: 1. Decreased crack cocaine abuse severity, operationalized as a decrease in crack cocaine use on quantitative GCMS in urine and on self-reported amounts and frequency of use, as increased control over crack cocaine craving, and as increased durations of abstinence and retention in drug treatment. 2. Increased utilization of formal and 12-step treatment services for crack cocaine abuse, operationalized using Natural History treatment exposure inventories. 3. Decreased multidimensional impairment operationalized as decreases of the non-drug dimensions of the Addiction Severity Index.