METHAMPHETAMINE ABUSE PHARMACOTHERAPY IN AIDS PATIENTS

艾滋病患者的甲基苯丙胺滥用药物治疗

• 批准号: 2715132
• 负责人: FRANK H GAWIN
• 金额: $ 3.63万
• 依托单位: FRIENDS RESEARCH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2715132
• 关键词: AIDS; clinical research; desipramine; drug abuse chemotherapy; drug addiction; gas chromatography mass spectrometry; high risk behavior /lifestyle; human subject; human therapy evaluation; methamphetamine; sertraline; sex behavior; therapy compliance; urinalysis

DESCRIPTION: (Applicant's Abstract) Methamphetarnine abuse in conjunction with sexual activity is now epidemic among homosexual and bisexual males. We propose an investigation of the efficacy of two promising putative stimulant abuse pharmacotherapies, desipramine and sertraline, as abstinence facilitation treatments for metharnphetamine (MAMPH) dependence in a sample of homosexual and bisexual males with symptomatic AIDS. The pharmacotherapies will be applied as adjunctive treatment linked to a medical care clinic for AIDS. The investigation will employ a placebo controlled, double-blind, random assignment, three cell parallel group design that will assess 120 subjects during 12 week's of experimental treatment, with follow-up at 1, 3 and 6 months. We hypothesize that subjects on active desipramine or sertraline, but not placebo, will evidence: 1. Decreased MAMPH abuse severity, operationalized as a decrease in MAMPH use on quantitative GCMS in urine and on self-reported amounts and frequency of use, as increased control over MAMPH craving and as increased durations of abstinence and retention in drug treatment. 2. Increased utilization of medical services for AIDS, operationalized as increases on measures of engagement attendance, and compliance with prescribed domains of AIDS medical care. 3. Decreased frequency of high risk sexual behaviors and of drug use in conjunction with sexual activity operationalized as decreases in self-reports of unsafe sexual behaviors and concurrent drug use on sexual behavior assessments.

描述：（申请人摘要） 与性活动相关的甲基苯丙胺滥用现已流行 在同性恋和双性恋男性中。 我们建议对两种有希望的假设的功效进行调查 兴奋剂滥用药物疗法，地昔帕明和舍曲林，作为戒断 样品中甲基苯丙胺 (MAMPH) 依赖性的促进治疗 患有艾滋病症状的同性恋和双性恋男性。 这 药物疗法将作为与以下疾病相关的辅助治疗 艾滋病医疗诊所。 该调查将采用安慰剂对照、双盲、随机的方法 作业，三单元平行小组设计，将评估 120 名受试者 在 12 周的实验治疗期间，并在第 1、3 和 6 周进行随访 几个月。 我们假设服用活性地昔帕明或舍曲林的受试者， 但不是安慰剂，将证明： 1. MAMPH 滥用严重程度降低，表现为 MAMPH 的减少 用于尿液中定量 GCMS 以及自我报告的量和频率 增加对 MAMPH 渴望的控制以及增加持续时间 药物治疗中的戒断和保留。 2. 提高艾滋病医疗服务的利用率，具体实施为 增加参与出席率和遵守规定的措施 艾滋病医疗保健的规定领域。 3. 高危性行为和吸毒频率减少 随着性活动的减少而实施 自我报告不安全的性行为和同时吸毒的性行为 行为评估。