LONGITUDINAL TRACING OF PRENATAL COCAINE ABUSE

越来越多的文献表明，产前接触可卡因会使 对后代的影响可能表现为神经行为 儿童的缺陷。 与此同时，目前几乎所有的实验室 动物数据基于在新生儿或青少年中进行的评估 啮齿动物 很少有数据表明， 可能出现在成年期，特别是在老年。 的 后一阶段尤其重要，因为随着年龄的增长，储备金 大脑的容量可能不再足以补偿 在大脑发育早期造成的伤害。 这种互动是 据推测，这是加速神经退行性疾病发作的原因。 帕金森病等疾病。 该问题将在妊娠期间暴露的大鼠中解决，通过 母亲服用可卡因 在3-8、9-14、15-20和21-26 月龄时，将评估各组大鼠的潜在损伤 通过各种复杂的性能检测。 这些措施包括： 认知功能（延迟选择），运动能力（转轮 性能）和药物辨别能力（区分 针对特定神经递质系统的药剂的作用）。 这些 将通过神经化学分析补充措施，旨在 多巴胺系统，旨在确定是否与年龄有关的变化， 大脑的化学成分已经被发育期的暴露所改变。 这些 研究结果将有助于估计孕产妇死亡带来的全部风险。 可卡因滥用及其对社区的潜在影响。

A growing literature indicates that prenatal exposure to cocaine exerts effects on the offspring that may be manifested as neurobehavioral deficits in children. In parallel, almost all of the current laboratory animal data are based on assessments conducted in neonatal or juvenile rodents. Few data are available to suggest the kinds of deficits that may appear during adulthood, and, especially, during advanced age. The latter period is especially important because, with aging, the reserve capacity of the brain may no longer be sufficient to compensate for damage inflicted during early brain development. Such an interaction is speculated to account for an accelerated onset of neurodegenerative disorders such as Parkinson's Disease. This question will be addressed in rats exposed during gestation, via maternal administration to cocaine. At 3-8, 9-14, 15-20, and 21-26 months of age, separate groups of rats will be assessed for latent damage by a variety of complex performance assays. These include measures of cognitive function (delayed choice), motor competence (running wheel performance), and drug discrimination capacity (ability to differentiate the effects of agents aimed at specific neurotransmitter systems). These measures will be supplemented by neurochemical assays, aimed at the dopamine system, designed to determine whether age-related variations in brain chemistry have been changed by the developmental exposure. These results will help estimate the full range of risks posed by maternal cocaine abuse and their potential impact on the community.