ACOUSTIC DISTORTION AND COCHLEAR STATUS

这项研究的总体目标是探索失真的限度 产品耳声发射(DPOAE)测量并确定 人类DPOAE参数与耳蜗声损伤的关系这 总体目标将在一系列实验中解决，在这些实验中， 主要问题是(1)在多大程度上 从DPOAE测量可以预测听力损失；(2)耳蜗术 一个频段的损伤会影响另一个频段的DPOAE测量 地区？；(3)在低频下测得的DPOAE能量较低吗？ 对于高频和影响这种结果的因素：；(4) 正常耳朵DPOAE潜伏期的测量取决于强度和剂量 在受损的耳朵中，它们变短，反映出非线性行为的丧失。 (5)DPOAE滤光片的形状和/或位置是否受听力影响 损失。统计学原理，其中许多已应用于临床 其他医学学科(即放射学)的决定将在这里使用 来评估这些数据。在回答上述问题时，将努力 致力于听力损失患者的大规模研究，项目 旨在提供信息，帮助确定最佳的 测试性能的条件，以及应提供 更深入地了解人类耳蜗加工的各个方面。这些 研究最终可能导致技术的发展，从而导致 更好地了解耳蜗性听力损失的后果 人类，它发生在大约2200万美国公民中。

The overall goal of this research is to explore the limits of distortion product otoacoustic emissions (DPOAE) measurements and to determine the relation between DPOAE parameters and cochlear damage in humans. This general goal will be addressed in a series of experiments in which the primary questions are (1) how well can the presence and magnitude of hearing loss be predicted from DPOAE measurements?; (2) does cochlear damage in one frequency region influence DPOAE measurements from other regions?; (3) is less DPOAE energy measured in the low frequencies compared to high frequencies and what are the factors affecting this outcome:; (4) do measures of DPOAE latencies in normal ears depend on intensity and do they shorten in impaired ears, reflecting the loss in nonlinear behavior"; (5) is the shape and/or location of the DPOAE filter affected by hearing loss. Statistical principles, many of which have been applied to clinical decisions in other medical disciplines (i.e., radiology), will be used here to evaluate these data. In answering the above questions, efforts will be devoted to large scale studies in patients with hearing loss, to projects designed to provide information that will help to determine the optimum conditions for test performance, and to projects that should provide greater insight into aspects of cochlear processing in humans. These studies eventually may lead to the development of techniques that result in a greater understanding of the consequences of cochlear hearing loss in humans, which occurs in approximately 22 million U.S. citizens.