Making muscle: molecular dissection of membrane domain formation

为了让肌肉对电信号做出有效的反应，它需要形成一个广泛的中空膜小管系统，信号可以通过这些系统传播。这项建议解决了在骨骼肌中形成这个小管系统的分子机制。该项目将在整个生物体而不是细胞培养系统中发展细胞生物学，并为澳大利亚和国际细胞生物学家提供一个新的框架。它将产生新的知识，培训年轻的澳大利亚科学家，帮助建立国际合作网络，并让研究社区以外的公众参与进来。

For a muscle to contract efficiently in response to an electrical signal it requires the formation of an extensive system of hollow membranous tubules through which the signal can be propagated. This proposal addresses the molecular mechanisms involved in the formation of this tubule system in skeletal muscle. This project will develop cell biology in a whole organism rather than a cell culture system and provide a new framework for Australian and international cell biologists. It will generate new knowledge, train young Australian scientists, help build international collaborative networks and engage the public outside the research community.