NATURAL HISTORY OF TREATED AND UNTREATED URINARY BLADDER OBSTRUCTION IN DOGS

狗治疗和未治疗膀胱尿路梗阻的自然史

• 批准号: 3753992
• 负责人: JACEK MOSTWIN
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3753992
• 关键词: androgens; benign prostate hyperplasia; biological models; dogs; estrogens; histology; hormone regulation /control mechanism; male reproductive system surgery; model design /development; pathologic process; physiology; urinary bladder; urinary tract obstruction

This is a proposal to establish and characterize an adult canine model for the study of treated and untreated bladder outflow obstruction caused by hormonally induced prostatic hyperplasia. The only mammals in which benign prostatic hyperplasia spontaneously occurs are man and dog. For this reason, the canine prostate has been an excellent model for studying the hormonal basis of prostatic growth and hyperplasia. In man, the leading causes of morbidity from prostatic enlargement are due to bladder outlet obstruction. In the dog, these symptoms have not been produced because the dog lacks a capsule similar to man. Investigators have thus been unable to study the effects of gradual obstruction in a mature or senescent mammalian model. We propose to establish a model of bladder outlet obstruction as close to the human condition as possible. A surgical capsule will be implanted around the canine prostate to provide maximum anatomical similarity of the human situation. The prostate will be subjected to controlled hormonal stimulation to produce gradual growth and obstruction. The effects of obstruction on organ appearance, performance and composition will be evaluated by means of urodynamic, cystoscopic, histological and biochemical study. Finally, the effects of treatment, by removal of the capsule and the obstructing prostate, will be evaluated.

这是一个建议，建立和表征成年犬模型， 膀胱出口梗阻治疗与未治疗的对比研究 激素诱导的前列腺增生。 唯一一种 前列腺增生症在人和狗中自发发生。 为此 因此，狗的前列腺一直是研究前列腺增生的极好模型。 前列腺生长和增生的激素基础。 在人类中， 前列腺肥大的发病原因是由于膀胱出口 梗阻 在狗身上，这些症状并没有产生，因为 狗缺少一个类似于人的胶囊。因此，调查人员无法 研究逐渐阻塞对成熟或衰老哺乳动物的影响 模型 我们建议建立一个膀胱出口梗阻模型， 尽可能地改善人类的状况。 手术舱将被植入 围绕犬前列腺，以提供最大的解剖相似性， 人类的处境。 前列腺会受到控制的激素 刺激产生逐渐增长和阻塞。 的影响 对器官外观、性能和组成的阻碍将是 通过尿流动力学、膀胱镜、组织学和生物化学方法进行评价 study. 最后，治疗的效果，通过去除胶囊和 阻塞的前列腺将被评估。