NATURAL HISTORY OF TREATED AND UNTREATED URINARY BLADDER OBSTRUCTION IN DOGS

这是一项建立和表征成年犬的动物模型的建议。 膀胱流出道梗阻治疗与未治疗的对比研究 激素诱导的前列腺增生症。唯一一种良性的哺乳动物 自发性发生的前列腺增生症有人和狗。为了这个 原因是，狗的前列腺一直是研究 前列腺生长和增生的激素基础。在人类中，领先者 前列腺肥大的发病原因是由于膀胱出口 障碍物。在狗身上，这些症状没有产生是因为 狗缺乏与人类相似的胶囊。因此，调查人员无法 研究渐进性梗阻对成熟或衰老哺乳动物的影响 模特。 我们建议建立一种接近膀胱出口梗阻的模型。 尽可能地改善人类的状况。将植入一个外科胶囊 在犬前列腺周围提供最大的解剖学相似性 人类的处境。前列腺会受到激素的控制 刺激产生逐渐生长和阻碍。的影响 器官外观、性能和组成上的障碍将被 通过尿动力学、膀胱镜、组织学和生化检查进行评估 学习。最后，治疗的效果，通过取出胶囊和 梗阻的前列腺，将被评估。

This is a proposal to establish and characterize an adult canine model for the study of treated and untreated bladder outflow obstruction caused by hormonally induced prostatic hyperplasia. The only mammals in which benign prostatic hyperplasia spontaneously occurs are man and dog. For this reason, the canine prostate has been an excellent model for studying the hormonal basis of prostatic growth and hyperplasia. In man, the leading causes of morbidity from prostatic enlargement are due to bladder outlet obstruction. In the dog, these symptoms have not been produced because the dog lacks a capsule similar to man. Investigators have thus been unable to study the effects of gradual obstruction in a mature or senescent mammalian model. We propose to establish a model of bladder outlet obstruction as close to the human condition as possible. A surgical capsule will be implanted around the canine prostate to provide maximum anatomical similarity of the human situation. The prostate will be subjected to controlled hormonal stimulation to produce gradual growth and obstruction. The effects of obstruction on organ appearance, performance and composition will be evaluated by means of urodynamic, cystoscopic, histological and biochemical study. Finally, the effects of treatment, by removal of the capsule and the obstructing prostate, will be evaluated.