NATURAL HISTORY OF TREATED AND UNTREATED URINARY BLADDER OBSTRUCTION IN DOGS

狗治疗和未治疗膀胱尿路梗阻的自然史

• 批准号: 5210357
• 负责人: JACEK MOSTWIN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5210357
• 关键词: androgens; benign prostate hyperplasia; biological models; dogs; estrogens; histology; hormone regulation /control mechanism; male reproductive system surgery; model design /development; pathologic process; physiology; urinary bladder; urinary tract obstruction

This is a proposal to establish and characterize an adult canine model for the study of treated and untreated bladder outflow obstruction caused by hormonally induced prostatic hyperplasia. The only mammals in which benign prostatic hyperplasia spontaneously occurs are man and dog. For this reason, the canine prostate has been an excellent model for studying the hormonal basis of prostatic growth and hyperplasia. In man, the leading causes of morbidity from prostatic enlargement are due to bladder outlet obstruction. In the dog, these symptoms have not been produced because the dog lacks a capsule similar to man. Investigators have thus been unable to study the effects of gradual obstruction in a mature or senescent mammalian model. We propose to establish a model of bladder outlet obstruction as close to the human condition as possible. A surgical capsule will be implanted around the canine prostate to provide maximum anatomical similarity of the human situation. The prostate will be subjected to controlled hormonal stimulation to produce gradual growth and obstruction. The effects of obstruction on organ appearance, performance and composition will be evaluated by means of urodynamic, cystoscopic, histological and biochemical study. Finally, the effects of treatment, by removal of the capsule and the obstructing prostate, will be evaluated.

这是一项建立并表征成年犬模型的提案 经治疗和未经治疗的膀胱流出道阻塞的研究 激素诱发的前列腺增生。 唯一具有良性的哺乳动物 自发发生前列腺增生的有人和狗。 为了这 因此，犬前列腺一直是研究前列腺癌的绝佳模型。 前列腺生长和增生的激素基础。 在人身上，领先的是 前列腺肥大发病的原因是膀胱出口 梗阻。 在狗身上，这些症状还没有出​​现，因为 狗和人一样缺乏胶囊。 因此调查人员无法 研究逐渐阻塞对成熟或衰老哺乳动物的影响 模型。 我们建议建立一个尽可能接近的膀胱出口梗阻模型 人类状况尽可能。 将植入手术胶囊 围绕犬前列腺，以提供最大的解剖相似性 人的情况。 前列腺将受到荷尔蒙控制 刺激产生逐渐生长和阻塞。 的影响 器官外观、性能和组成受阻 通过尿动力学、膀胱镜、组织学和生化评估 学习。 最后，通过去除胶囊和进行治疗的效果 前列腺阻塞，将进行评估。