OLFACTORY EVOKED POTENTIALS IN CLINICAL POPULATIONS

临床人群中的嗅觉诱发电位

• 批准号: 2127184
• 负责人: CLAIRE L MURPHY
• 金额: $ 22.01万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2127184
• 关键词: age difference; diagnosis design /evaluation; evoked potentials; human subject; olfactions; olfactory disorder; olfactory stimulus; olfactory threshold

This project is designed to investigate fundamental questions regarding the sensory and cognitive basis of the olfactory evoked potential (OEP), and the application of the OEP in clinical settings where an objective index of sensory function has importance. The project will begin with parametric manipulation of stimulus and recording variables to elicit the most consistent, reliable, and robust OEP recordings. Once this has been accomplished, a study will commence to determine the capability of the individual person's OEP to indicate the functional olfactory status of that individual. This goal will be approached systematically by studying normal individuals.of various ages, including the elderly, and patients from the Nasal Dysfunction Clinic at the University of California, San Diego Medical Center who are known from precise psychophysical testing to be hyposmic, parosmic, phantosmic, or anosmic. State-of-the-art psychophysical measures of olfactory function will be utilized to characterize individuals and then compare OEPs for those individuals l) with their function measured psychophysically, and 2) against age- normative average OEP for the group, which will be collected. The individual's OEP will be compared to the auditory and visual evoked potentials for anosmics, hyposmics, and normals. Because one of the ultimate goals of this project is to use the OEP in various clinical populations who show olfactory dysfunction, including Alzheimer's patients, the feasibility of using the technique with demented individuals will be investigated. In the latter phase of the project, the possibility of recording an olfactory P3, using a variant of the "odd-ball paradigm," and its usefulness in clinical populations will be investigated.

该项目旨在调查有关以下方面的基本问题 嗅觉诱发电位（OEP）的感觉和认知基础， 以及OEP在临床环境中的应用， 感觉功能指标具有重要意义。该项目将开始于 刺激和记录变量的参数操作，以引出 最一致、最可靠和最强大的OEP记录。一旦这已经 完成后，将开始一项研究，以确定 个人的OEP，以表明功能性嗅觉状态 那个人。这一目标将通过研究 不同年龄的正常人，包括老年人和患者 来自加州大学旧金山分校的鼻功能障碍诊所 迭戈医疗中心谁是已知的精确的心理物理测试， 嗅觉减退、嗅觉异常、幻觉或嗅觉缺失。State-of-the-art 嗅觉功能的心理物理测量将被用于 描述个体特征，然后比较这些个体的OEP 与他们的功能测量心理，和2）对年龄- 将收集该组的标准平均OEP。的 将个体的OEP与听觉和视觉诱发的OEP进行比较， 嗅觉缺失、嗅觉减退和正常的可能性。因为其中一 本项目的最终目标是将OEP用于各种临床 嗅觉功能障碍的人群，包括阿尔茨海默氏症 患者，将该技术用于痴呆症患者的可行性 将进行调查。在项目的最后阶段， 使用“奇球范式”的变体记录嗅觉P3， 并将研究其在临床人群中的有用性。