OLFACTORY EVOKED POTENTIALS IN CLINICAL POPULATIONS

该项目旨在调查以下基本问题 嗅觉诱发电位的感觉和认知基础， 以及OEP在临床环境中的应用，其中 感觉功能指标具有重要意义。该项目将从以下方面开始 刺激和记录变量的参数操纵以引出 最一致、可靠和可靠的OEP录音。一旦这件事发生了 完成后，将开始一项研究，以确定 个人的OEP来指示功能性嗅觉状态 那个人。这一目标将通过研究有系统地实现 不同年龄段的正常人，包括老年人和病人 来自加州大学旧金山分校的鼻功能障碍诊所 迭戈医学中心从精确的心理物理测试到 是低渗的、低渗的、幻觉的或无渗的。最先进的 嗅觉功能的心理物理测量将被用于 确定个体的特征，然后比较这些个体的OPS(L) 通过心理生理测量他们的功能，以及2)相对于年龄- 集团的标准平均OEP，将被收集。这个 个体的OEP将与听觉和视觉诱发的 嗅觉减退、发育不良和正常的潜势。因为其中一个 该项目的最终目标是将OEP用于各种临床 表现为嗅觉功能障碍的人群，包括阿尔茨海默氏症 患者，对痴呆症患者使用该技术的可行性 将会被调查。在项目的后期阶段，有可能 记录一个嗅觉P3，使用一种变种的“奇球范式”， 并将调查其在临床人群中的有效性。

This project is designed to investigate fundamental questions regarding the sensory and cognitive basis of the olfactory evoked potential (OEP), and the application of the OEP in clinical settings where an objective index of sensory function has importance. The project will begin with parametric manipulation of stimulus and recording variables to elicit the most consistent, reliable, and robust OEP recordings. Once this has been accomplished, a study will commence to determine the capability of the individual person's OEP to indicate the functional olfactory status of that individual. This goal will be approached systematically by studying normal individuals.of various ages, including the elderly, and patients from the Nasal Dysfunction Clinic at the University of California, San Diego Medical Center who are known from precise psychophysical testing to be hyposmic, parosmic, phantosmic, or anosmic. State-of-the-art psychophysical measures of olfactory function will be utilized to characterize individuals and then compare OEPs for those individuals l) with their function measured psychophysically, and 2) against age- normative average OEP for the group, which will be collected. The individual's OEP will be compared to the auditory and visual evoked potentials for anosmics, hyposmics, and normals. Because one of the ultimate goals of this project is to use the OEP in various clinical populations who show olfactory dysfunction, including Alzheimer's patients, the feasibility of using the technique with demented individuals will be investigated. In the latter phase of the project, the possibility of recording an olfactory P3, using a variant of the "odd-ball paradigm," and its usefulness in clinical populations will be investigated.