OLFACTORY EVOKED POTENTIALS IN CLINICAL POPULATIONS

临床人群中的嗅觉诱发电位

• 批准号: 6516126
• 负责人: CLAIRE L MURPHY
• 金额: $ 22.32万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516126
• 关键词: Alzheimer's disease; age difference; brain injury; clinical research; diagnosis design /evaluation; evoked potentials; human subject; nervous system disorder diagnosis; olfactions; olfactory disorder; olfactory stimulus; olfactory threshold

DESCRIPTION:(adapted from applicant's abstract) This project is designed to investigate fundamental questions regarding the sensory and cognitive basis of the olfactory event-related brain potential (OERP), as well as to advance clinical application of the OERP in settings where an objective index of olfactory function has importance. Building on the foundation laid by the initial grant period, the current project proposes to further refine the event-related potential technology to optimize its application in both research and clinical contexts. Research during the initial project period has demonstrated that OERPs show age-associated changes in latency and amplitude over the adult lifespan. Nothing is yet known regarding the OERP in children in health or disease. Therefore, the current application proposes to investigate the OERP in normally developing children. Research during the initial project period has demonstrated that adult patients with traumatic brain injury (TBI) show olfactory loss that is objectively reflected in both early N1/P2 and late P3 OERP components. Adults and children with TBI will be followed over time to determine whether recovery of function can be quantified objectively and whether or not the developing olfactory system of children may recover more quickly than that of the adult. Progress during the current grant period has also shown that the OERP is reflective of the olfactory dysfunction in Alzheimer's disease. The magnitude of the effects on the olfactory ERP is substantially larger than has been observed with auditory ERPs. Identification of pre-clinical markers and more accurate early diagnosis of Alzheimer's disease are critically important. This application addresses the issue of early detection of olfactory dysfunction in individuals at risk for Alzheimer's disease. Early detection of the disease will ensure early medical and social intervention for the patient and family caregivers.

描述：（改编自申请人摘要） 该项目旨在调查有关 嗅觉事件相关脑电位的感觉和认知基础 （OERP），以及推进OERP在环境中的临床应用 其中嗅觉功能的客观指标具有重要性。基础上 在最初赠款期奠定的基础上，本项目提出， 进一步完善与事件相关的潜在技术， 在研究和临床环境中应用。初期研究 项目期间已经表明，OERP显示出与年龄相关的变化， 潜伏期和振幅。目前还不清楚 健康或疾病儿童的OERP。因此，目前的应用 建议调查正常发育儿童的OERP。研究 在最初的项目期间，已经证明， 外伤性脑损伤（TBI）表现为嗅觉丧失，这是客观反映 在N1/P2早期和P3晚期OERP成分中均存在显著性差异。成人和儿童TBI 将随着时间的推移进行随访，以确定功能恢复是否可以 客观地量化，以及是否发展中的嗅觉系统， 儿童可能比成人恢复得更快。内的进展 目前的赠款期间也表明，OERP是反映了 阿尔茨海默病的嗅觉障碍影响的程度 嗅觉ERP明显大于听觉ERP ERP。识别临床前标志物和更准确的早期诊断 是非常重要的。此应用程序解决了 嗅觉障碍早期诊断问题 老年痴呆症早期发现疾病将确保早期医疗 以及对患者和家庭护理人员的社会干预。