OLFACTORY EVOKED POTENTIALS IN CLINICAL POPULATIONS

临床人群中的嗅觉诱发电位

• 批准号: 6379325
• 负责人: CLAIRE L MURPHY
• 金额: $ 22.24万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379325
• 关键词: Alzheimer's disease; age difference; brain injury; clinical research; diagnosis design /evaluation; evoked potentials; human subject; nervous system disorder diagnosis; olfactions; olfactory disorder; olfactory stimulus; olfactory threshold

DESCRIPTION:(adapted from applicant's abstract) This project is designed to investigate fundamental questions regarding the sensory and cognitive basis of the olfactory event-related brain potential (OERP), as well as to advance clinical application of the OERP in settings where an objective index of olfactory function has importance. Building on the foundation laid by the initial grant period, the current project proposes to further refine the event-related potential technology to optimize its application in both research and clinical contexts. Research during the initial project period has demonstrated that OERPs show age-associated changes in latency and amplitude over the adult lifespan. Nothing is yet known regarding the OERP in children in health or disease. Therefore, the current application proposes to investigate the OERP in normally developing children. Research during the initial project period has demonstrated that adult patients with traumatic brain injury (TBI) show olfactory loss that is objectively reflected in both early N1/P2 and late P3 OERP components. Adults and children with TBI will be followed over time to determine whether recovery of function can be quantified objectively and whether or not the developing olfactory system of children may recover more quickly than that of the adult. Progress during the current grant period has also shown that the OERP is reflective of the olfactory dysfunction in Alzheimer's disease. The magnitude of the effects on the olfactory ERP is substantially larger than has been observed with auditory ERPs. Identification of pre-clinical markers and more accurate early diagnosis of Alzheimer's disease are critically important. This application addresses the issue of early detection of olfactory dysfunction in individuals at risk for Alzheimer's disease. Early detection of the disease will ensure early medical and social intervention for the patient and family caregivers.

描述：(改编自申请者摘要) 该项目旨在调查有关 嗅觉事件相关脑电位的感觉和认知基础 (OERP)，以及推进OERP在环境中的临床应用 其中，嗅觉功能的客观指标具有重要意义。建立在 由最初的资助期奠定的基础，目前的项目建议 进一步细化事件相关电位技术，优化其 在研究和临床环境中的应用。在最初的研究中 项目期表明，OERP显示出与年龄相关的变化 成人寿命的潜伏期和波幅。目前还不知道关于 健康或疾病儿童的OERP。因此，当前的应用程序 建议对正常发育儿童的OERP进行调查。研究 在最初的项目期间，已经证明成年患者患有 创伤性脑损伤(TBI)是指客观反映的嗅觉丧失。 在N1/P2早期和P3晚期OERP成分中。成人和儿童脑外伤 将随着时间的推移进行跟踪，以确定功能是否可以恢复 客观地量化和发展中的嗅觉系统 儿童可能比成年人恢复得更快。在这方面的进展 目前的授权期也表明，项目资源计划反映了 阿尔茨海默病患者的嗅觉功能障碍。影响的大小 嗅觉ERP比用听觉观察到的要大得多。 ERPS。临床前标志物的识别和更准确的早期诊断 阿尔茨海默氏症的风险是至关重要的。此应用程序解决了 嗅觉功能障碍高危人群的早期发现问题 阿尔茨海默氏症。及早发现这种疾病将确保及早就医 以及对患者和家庭照顾者的社会干预。