Understanding evolution of dominant bacteria inhabiting the rodent gut

了解啮齿动物肠道中优势细菌的进化

• 批准号: DP200101980
• 负责人: Prof Philip Hugenholtz
• 金额: $ 55.11万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101980
• 关键词: Understanding; evolution; dominant; bacteria; inhabiting

The gut microbiome is central to animal health and immune function, however we have an incomplete understanding of how this important symbiotic ecosystem evolved. By approaching this knowledge gap from a historical perspective and using real-time observation, this project will address how the gut community evolved with the rodent host and how members of that community respond to new selective pressures. The significance of these findings is in their capacity to inform our understanding of the relationship between host and microbe, not only within a key model system, but by extrapolation to other host-microbe systems.

肠道微生物群是动物健康和免疫功能的核心，然而我们对这个重要的共生生态系统是如何进化的了解还不完全。通过从历史的角度探讨这一知识差距并使用实时观察，该项目将研究肠道群落如何与啮齿动物宿主一起进化，以及该群落的成员如何应对新的选择压力。这些发现的意义在于，它们能够让我们了解宿主和微生物之间的关系，不仅是在一个关键的模型系统内，而且是通过推断到其他宿主-微生物系统。