Mechanisms that control the inheritance of mitochondrial DNA mutations

控制线粒体 DNA 突变遗传的机制

• 批准号: DP200101630
• 负责人: A/Prof Steven Zuryn
• 金额: $ 31.6万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-05-31 至 2023-05-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101630
• 关键词: Mechanisms; control; inheritance; mitochondrial; DNA

How do humans and other organisms prevent the accumulation of dangerous mitochondrial genome (mtDNA) mutations across generations? This Project aims to uncover the cellular and molecular pathways that help prevent the inheritance of mtDNA mutations to offspring by employing cutting-edge genetic technologies that the laboratory has recently developed in the germline of an animal model system. This Project will generate new knowledge in the area of mitochondrial genetics and evolution. Expected outcomes include the development of new theories for mtDNA inheritance, which should provide significant benefits for agricultural breeding programs and the interpretation of mtDNA inheritance patterns in the human population.

人类和其他生物如何防止危险的线粒体基因组（mtDNA）突变在几代人之间的积累？该项目旨在通过采用实验室最近在动物模型系统的种系中开发的尖端遗传技术，揭示有助于防止mtDNA突变遗传给后代的细胞和分子途径。该项目将产生线粒体遗传学和进化领域的新知识。预期的结果包括发展新的mtDNA遗传理论，这将为农业育种计划和人类mtDNA遗传模式的解释提供重大好处。