SPECIFIC REPRESSION OF PROLACTIN GENE EXPRESSION

催乳素基因表达的特异性抑制

• 批准号: 2143170
• 负责人: RICHARD N DAY
• 金额: $ 12.35万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-11 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2143170
• 关键词: SPECIFIC; REPRESSION; PROLACTIN; GENE; EXPRESSION

DESCRIPTION (adapted from the applicant's abstract): The objective of the proposed studies is to identify the critical molecular events that direct specific repression of PRL gene expression. Aim 1 is to establish the importance of the alternative splice form of Pit-1 in the repression of PRL and to determine the molecular events that contribute to the splice choice. Aim 2 is to determine if specific DNA elements in the PRL gene are the key determinants of why PRL gene expression is inhibited in GH3 cell-induced tumors, while GH gene expression is not. Aim 3 will be to examine the interaction of proteins with the PRL and GH promoters, and to characterize the proteins that are involved in the specific repression of the PRL gene.

描述（改编自申请人的摘要）：目的