ORGANOCHLORINE RESIDUE LEVELS AND RISK OF BREAST CANCER

有机氯残留水平和乳腺癌风险

• 批准号: 2156188
• 负责人: LESLIE BERNSTEIN
• 金额: $ 19.01万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2156188
• 关键词: African American; blood chemistry; blood lipid; breast neoplasms; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; chlordane; chlorohydrocarbon insecticide; dichlorodiphenyltrichloroethane; dioxins; environmental toxicology; female; halobiphenyl /halotriphenyl compound; human middle age (35-64); human subject; insecticide biological effect; interview; pesticide interaction; pesticide residues; statistics /biometry; women's health; young adult human (21-34)

Organochlorine compounds such as DDT and PCB are detectable in the blood of most Americans. These compounds have been designated as possibly or probably carcinogenic by the International Agency for Research on Cancer. Some recent reports suggest that risk of breast cancer is proportional to exposure to DDE, a degradation product of DDT, and to PCB. These reports were each based on fewer than 60 cases. Results from another, larger study suggest no associations exist; additional data are needed. African- Americans have had greater exposure to DDE than white Americans, thus an examination of the DDE-breast cancer association in African-Americans may have greater statistical power to detect an effect than studies in lesser- exposed populations. We propose to conduct a case-control study to test the hypothesis that levels of organochlorine residues in serum are associated with increased risk of breast cancer among African-American women. The study will be added on to ongoing study funded by the National Institute of Child Health and Development. The ongoing study, the Women's Contraceptive and Reproductive Experience (CARE) study, is a multi-center population-based case-control study being conducted among women aged 35-64 in five areas of the U.S., including Los Angeles County. For the present study, we will enroll a subset of the African-American participants in Los Angeles County. Cases will be identified through the Los Angeles County Cancer Surveillance Program (a SEER cancer registry).. Controls will be selected by random-digit dialing. After subjects have completed interviews for the Women's CARE study, they will be asked to provide a blood specimen for the present study. We will obtain blood from 300 African-American breast cancer cases and 300 controls and measure serum organochlorine residues (DDE, PCBs, heptachlor epoxide, oxychlordane, trans-nonachlor, dieldrin, HCB, and beta-BHC) and total lipids using standard methods. Serum residue levels will be examined in relation to odds of breast cancer in multivariate unconditional logistic regression models.

有机氯化合物，如滴滴涕和多氯联苯是在血液中检测 大多数美国人。 这些化合物已被指定为可能或 国际癌症研究机构认为可能致癌。 最近的一些报告表明，患乳腺癌的风险与 接触DDE（DDT的降解产物）和PCB。 这些报告 都是基于少于60个案例。另一项更大规模研究的结果 表明不存在关联;需要更多数据。 非洲- 美国人比白色美国人更容易接触到DDE，因此， 在非裔美国人中进行DDE-乳腺癌相关性检查， 有更大的统计力量来检测效果比研究在较小的- 暴露人群。 我们建议进行一项病例对照研究，以检验这一假设， 血清中有机氯残留物的水平与 非裔美国妇女患乳腺癌的风险。 本研究将 这是由国家儿童健康研究所资助的正在进行的研究的补充 发展先行者的要求 正在进行的研究，妇女避孕和 生殖经验（CARE）研究是一项基于多中心人群的研究， 在五个地区对35-64岁的妇女进行病例对照研究， 美国，包括洛杉矶县。 在本研究中，我们将 在洛杉矶招募一部分非裔美国人参与者 县 病例将通过洛杉矶县癌症中心确定 监测计划（SEER癌症登记）。 将选择对照品 通过随机数字拨号 受试者完成面试后 妇女的护理研究，他们将被要求提供血液标本， 本研究。 我们将从300名非洲裔美国乳腺癌患者和300名 控制和测量血清有机氯残留物（DDE，PCB，七氯 环氧化物、氧氯草胺、反式-九氯、狄氏剂、六氯苯和β-六六六）， 使用标准方法测定总脂质。 血清残留水平将是 在多变量中检查与乳腺癌几率的关系 非条件Logistic回归模型