VISUAL-SPATIAL PROPERTIES OF AREA NEURONS

区域神经元的视觉空间特性

• 批准号: 2159461
• 负责人: RICHARD A ANDERSEN
• 金额: $ 26.21万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2159461
• 关键词: Macaca mulatta; auditory stimulus; behavior test; brain electrical activity; brain mapping; eye movements; head movements; histology; memory; neural information processing; neuroanatomy; neurophysiology; parietal lobe /cortex; single cell analysis; space perception; vision tests; visual pathways; visual stimulus

Lesions to the inferior parietal lobule (IPL) in humans from stroke, cerebral trauma, or tumors, produce deficits in complex cortical functions including spatial perception and visuomotor integration. Similar deficits are found with lesions to IPL (also known as area 7) in monkeys, indicating that monkeys provide an appropriate model for beginning to understand the function of this area in humans. In the experiments in this proposal we will examine the role of IPL in visuomotor and spatial functions by recording from and microstimulating this area in awake, behaving monkeys. These experiments will investigate the role of this area in the processing of spatial information, with special emphasis on its role in coordinate transformations. Previous experiments in this area indicated that eye position and retinal position information converged onto single cells and may produce a representation of visual space in head-centered coordinates. One set of experiments will examine the possibility that activity related to head position is also found for these same cells, and is integrated in a similar way to the eye position signals, consistent with an encoding of locations in body-centered coordinates. We will also examine if the saccade-related activity in the lateral intraparietal area (LIP) is coding gaze shifts, which can include combined eye and head movements, rather than simply eye movements. In a second set of experiments related to coordinate transformations, we will examine if a newly found auditory-related activity in area IPL is coded in head or retinal coordinates, and if this activity is modulated by eye position in a similar way to the modulation for visual signals by eye position. These experiments may find that more than one modality uses the same coordinate transformation machinery in this area and would represent one of the first examples of how modalities are associated in the cortex. In another group of experiments we will examine the functional organization of IPL using cortical microstimulation techniques. These experiments will provide new data on the role of area LIP in eye movement functions. We will also examine the topographic organization of evoked responses in the different cortical areas in IPL to see if they contain orderly retinotopic or spatiotopic representations. In a final group of experiments we will examine the role of IPL in the formation of motor plans. We will be interested in a memory-linked activity that is prevalent in this area, and we will test the hypothesis that this activity is a neural correlate of the intention to make movements. These experiments will help us to understand the fundamental problem of how coordinates are transformed in proceeding from sensory input to motor output. They will also help us to understand how high level cortical functions such as motor plans are processed in this visuomotor pathway.

人类中风引起的顶下小叶（IPL）病变， 脑外伤或肿瘤会导致复杂的皮质 功能包括空间感知和视觉整合。 在IPL（也称为区域7）的病变中发现了类似的缺陷， 猴子，表明猴子提供了一个适当的模型， 开始了解这个区域在人类中的功能。 在 在这个实验中，我们将研究IPL在 通过记录和微刺激的视觉和空间功能 这一区域是清醒的猴子的大脑。 这些实验将研究这个区域在 空间信息的处理，特别强调其在 坐标变换 以前在这方面的实验表明， 眼睛位置和视网膜位置信息汇聚到单个 细胞，并可能产生以头部为中心的视觉空间的表示 坐标 一组实验将检验 也发现这些相同的细胞具有与头部位置相关的活动， 以与眼睛位置信号类似的方式积分， 以身体为中心的坐标编码位置。 我们还将 检查外侧顶内区的扫视相关活动是否 (LIP)正在编码视线转移，这可能包括眼睛和头部的组合 运动，而不仅仅是眼睛的运动。 的第二集合中 与坐标变换相关的实验，我们将检查 IPL区新发现的药物相关活性编码在头部或 视网膜坐标，如果这种活动是由眼睛的位置调制， 类似于通过眼睛位置对视觉信号进行调制的方式。 这些实验可能会发现，不止一种模态使用相同的 坐标变换机械在这一领域，并将代表一个 第一个例子是关于大脑皮层中的模式是如何联系的。 在另一组实验中，我们将检查函数 使用皮质微刺激技术组织强脉冲光。 这些 这些实验将为LIP区在眼球运动中的作用提供新的数据 功能协调发展的 我们还将研究诱发的拓扑组织 IPL中不同皮层区域的反应，以查看它们是否包含 有序的视网膜位置或空间位置表示。 在最后一组实验中，我们将研究IPL在 汽车计划的形成。 我们会对记忆连接的 活动是在这个地区普遍存在的，我们将测试的假设， 这种活动是一种神经关联的意图， 动作 这些实验将帮助我们理解 从感觉输入到运动输入过程中坐标是如何转换的 输出. 它们还能帮助我们了解大脑皮层 诸如运动计划的功能在该视觉通路中处理。