Heavy Metal Chemistry Goes Nuclear: Radioactive Rhenium and Terbium Agents

重金属化学走向核能：放射性铼和铽剂

• 批准号: DP230100276
• 负责人: Prof Paul Donnelly
• 金额: $ 30.26万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100276
• 关键词: Heavy; Metal; Chemistry; Goes; Nuclear

This project aims to make fundamental advances in the basic knowledge of the bioinorganic chemistry of radioactive metals that have the potential to be used in the future as radioactive drugs. Technological advances in the production of radioactive isotopes of rhenium and terbium have increased the feasibility of using these radionuclides as radioactive drugs, but their use requires new basic knowledge in their fundamental coordination chemistry. This project will develop new ways to synthesise radioactive rhenium and terbium complexes. The outcomes of this project will be an improved understanding of the coordination chemistry rhenium and terbium which is required to inform their future translation to new radiopharmaceuticals.

该项目的目的是在放射性金属的生物无机化学基础知识方面取得根本性进展，这些金属有可能在未来用作放射性药物。在生产放射性同位素氚和铽方面的技术进步增加了将这些放射性核素用作放射性药物的可行性，但它们的使用需要在其基本配位化学方面有新的基础知识。该项目将开发合成放射性铽和铽配合物的新方法。该项目的成果将是提高对配位化学物质铽和铽的理解，这是未来将其转化为新的放射性药物所必需的。