Gallium, Copper and Metal Fluoride Complexes Designed for Brain Imaging

专为脑成像设计的镓、铜和金属氟化物络合物

• 批准号: LP150100656
• 负责人: Prof Paul Donnelly
• 金额: $ 25.39万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-02-26 至 2019-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100656
• 关键词: Gallium; Copper; Metal; Fluoride; Complexes

This project aims to develop fundamental synthetic coordination chemistry directed toward the development of new agents for imaging brain perfusion using positron emission tomography. The research will focus on developing new coordination complexes containing positron-emitting isotopes of copper, gallium and fluorine. The goal is incorporate in these radionuclides into small molecules that can be used for the molecular imaging of the brain. This chemistry will have the potential to replace existing technologies that rely on single-photon emission from technetium and the technique of single photon emission computed tomography.

该项目旨在开发基础合成配位化学，用于开发使用正电子发射断层扫描成像脑灌注的新试剂。该研究将重点开发含有铜、镓和氟的正电子发射同位素的新型配位配合物。我们的目标是将这些放射性核素结合成小分子，用于大脑的分子成像。这种化学将有可能取代现有的技术，依赖于单光子发射从锝和单光子发射计算机断层扫描技术。