Site-specific Conjugation of Zirconium and Copper Complexes to Antibodies for Application in Diagnostic Imaging and Therapy

锆和铜络合物与抗体的位点特异性缀合在诊断成像和治疗中的应用

• 批准号: FT130100204
• 负责人: Prof Paul Donnelly
• 金额: $ 60.87万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100204
• 关键词: Site; specific; Conjugation; Zirconium; Copper

This project will focus on fundamental chemistry that underpins innovations in the synthesis of metal-based imaging and therapeutic agents. Radioactive isotopes of copper and zirconium can be used for either non-invasive diagnostic imaging or treatment of disease. However, it is essential that the diagnostic or therapeutic agent selectively localises in diseased tissue. This project aims to achieve the required selectivity by employing enzymatic site-specific bioconjugation reactions to build new imaging agents that feature ligands designed to safely bind radioactive isotopes fused to antibody derived targeting molecules.

该项目将专注于基础化学，这是合成金属成像和治疗剂的创新的基础。铜和锆的放射性同位素既可用于非侵入性诊断成像，也可用于疾病治疗。然而，诊断或治疗剂选择性地定位于病变组织是至关重要的。该项目旨在通过利用酶定位生物偶联反应来构建新的显像剂来实现所需的选择性，这些显像剂具有旨在安全地将融合到抗体衍生的靶向分子上的放射性同位素结合的配体。