The role of LIM Kinase 1 in neurons

LIM 激酶 1 在神经元中的作用

• 批准号: DP150104321
• 负责人: Prof Yazi Ke
• 金额: $ 30.7万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104321
• 关键词: role; LIM; Kinase; neurons

The aim of this project is to study LIM domain kinase 1 in neuronal function, using cell and mouse models. Unrestricted brain function is essential to one’s wellbeing and the ability to perform normally. Critically contributing to the function of neurons is a cytoskeleton which maintains morphology and function. However, molecular mechanisms underlying cytoskeletal dynamics are poorly understood. LIM domain kinase 1, a key regulator of the actin cytoskeleton decreased with age and its loss associated with deficits in memory and neuronal morphology. This project could reveal fundamental processes regulating and maintaining brain function.

本项目的目的是利用细胞和小鼠模型研究LIM结构域激酶1在神经元功能中的作用。不受限制的大脑功能对一个人的健康和正常工作的能力至关重要。维持形态和功能的细胞骨架对神经元的功能起关键作用。然而，细胞骨架动力学的分子机制知之甚少。LIM结构域激酶1是肌动蛋白细胞骨架的关键调节因子，随着年龄的增长而减少，其损失与记忆和神经元形态的缺陷有关。该项目可以揭示调节和维持大脑功能的基本过程。