MODELS OF CORRELATION BASED NEURAL DEVELOPMENT

神经发育后期的许多方面都是由 神经元活动。指导是由以下两种内在模式提供的 出生前和出生后的活动以及由以下因素引起的活动 出生后的经历。理论研究将解决以下问题 哺乳动物大脑发育中的活动依赖机制 大脑皮层。这种大脑皮层机制似乎在许多 人类健康的各个方面，例如在视觉障碍方面，如 斜视和弱视的恢复和重组 损伤或截肢后的躯体感觉或运动功能。 理论研究将解决以下四个具体问题 初级视皮层的发育：可能的关系(L) 在眼球优势、偏爱方向、视差调节、 首选空间频率和其他皮质感受场特性 当输入四种类型(从左到右的开中心和偏离中心)时 右眼)竞相支配二维皮层；(2) 通过以下方式引入皮质组织的其他效果 考虑到大脑皮层组织中的竞争 发生是三维的，并包含单独的抑制和 兴奋性神经元的分布；(3)眼内反射的影响 眼优势柱发育的相关性，特别是 这种相关性改变列宽的条件；(4) 当非线性时引入发展模型的变化 引入了皮质激活模式，就像在抽象模型中一样 由Kohonen介绍的皮质发育。 在所有四项研究中，目标都将是描述不同的 依赖活动可能导致的可能发展结果 机制，以及实验上可测量和可操作的因素 将决定实际结果，如果这种机制是发展的基础。 这将为假设的实验测试提供基础 这些机制构成了所研究现象的基础。额外的长期投资 目标是确定这种机制在设计中的功能 大脑皮层计算。第四个项目，通过提供到 抽象模型的集合，其计算函数可以是部分的 的特征，可能为这样的功能解释提供线索 大脑皮质发育中的活动依赖机制。

Many aspects of the later stages of neural development are guided by neuronal activity. Guidance is given both by intrinsic patterns of activity, before and after birth, and by activity resulting from experience after birth. Theoretical studies will address the role of activity-dependent mechanisms in the development of the mammalian cerebral cortex. Such cortical mechanisms appear to play an important role in many aspects of human health, for example in visual disorders such as strabismus and amblyopia, and in recovery and reorganization of somatosensory or motor function after injury or amputation. The theoretical studies will address four specific questions in the development of the primary visual cortex: (l) The relationships that may develop between ocular dominance, preferred orientation, disparity tuning, preferred spatial frequency, and other cortical receptive field properties when inputs of four types (ON-center and OFF-center from the left and right eyes) compete to innervate a two-dimensional cortical layer; (2) The additional effects that are introduced into cortical organization by consideration of the fact that the cortical tissue in which competition occurs is three dimensional, and contains separate inhibitory and excitatory neuronal populations; (3) The effects of interocular correlations on ocular dominance column development, in particular the conditions under which such correlations alter the column width; (4) The changes that are introduced into developmental models when nonlinear cortical activation patterns are introduced, as in the abstract models of cortical development introduced by Kohonen. In all four studies, the goal will be to characterize the different possible developmental outcomes that may result under activity-dependent mechanisms, and the experimentally measurable and manipulable factors that will determine the actual outcome if such mechanisms underlie development. This will provide a basis for experimental tests of the hypothesis that such mechanisms underlie the studied phenomena. An additional long-term goal is to determine the functions of such mechanisms in designing cortical computations. The fourth project, by providing a connection to a set of abstract models whose computational function can be partially characterized, may provide clues to such a functional interpretation of activity-dependent mechanisms in cortical development.