MOLECULAR GENETICS OF PHOTOTRANSDUCTION

光传导的分子遗传学

• 批准号: 2163464
• 负责人: BIH-HWA SHIEH
• 金额: $ 20.62万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2163464
• 关键词: Drosophilidae; electrophysiology; electroretinography; gene deletion mutation; gene expression; gene mutation; genetic markers; immunoprecipitation; membrane proteins; nucleic acid sequence; polymerase chain reaction; posttranslational modifications; visual photoreceptor; visual phototransduction; visual pigments; voltage /patch clamp

The long-term objective is to offer low-vision patients affordable means of maximizing use of residual vision for reading - at home, work, school and most other locations. Reading Assistant and Reading Service will customize and integrate computer and communication technologies with results of clinical research on how best to display text to patients with specific categories of visual impairment, including age-related losses. Aims of Phase I are: 1) Develop and test specialized fonts for improved recognition by patients 2) Determine best method(s) of presenting text to patients on monitor 3) Measure reading speed and comprehension with and without use of monitor, fonts and presentation styles 4) Assess requirements for improvements in scanning and OCR Methodology: measure reading function of four subject categories, including both old and young subjects, with and without new aids. Technological innovation will result from packaging of miniaturized components into integrated system customized to support patients' dual needs: improved use of residual vision, and portability. No devices and services with all these attributes currently exist. Target price is more affordable than available partial solutions.

长期目标是为低视力患者提供负担得起的手段 最大限度地利用残余视力进行阅读——在家、工作、学校 和大多数其他地点。 阅读助手和阅读服务将 定制并集成计算机和通信技术 关于如何最好地向患者显示文本的临床研究结果 特定类别的视力障碍，包括与年龄相关的视力丧失。 第一阶段的目标是： 1) 开发和测试专用字体以提高患者的识别度 2) 确定在监视器上向患者呈现文本的最佳方法 3) 测量使用或不使用阅读器的阅读速度和理解力 显示器、字体和演示风格 4) 评估扫描和 OCR 改进的要求 方法论：测量四个学科类别的阅读功能， 包括年老和年轻的受试者，有或没有新的辅助工具。 技术创新将源自小型化封装 组件集成到定制的集成系统中，以支持患者的双重 需求：改进残余视力的使用以及便携性。 没有设备和 目前存在具有所有这些属性的服务。 目标价多了 比现有的部分解决方案更实惠。