MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
慢性睑缘炎的睑板腺功能障碍
基本信息
- 批准号:2163864
- 负责人:
- 金额:$ 14.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-09-30 至 1995-09-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Our goal is to understand chronic blepharitis, the role of the meibomian
gland in blepharitis and the effect of meibomian gland loss on the
dynamics of ocular evaporation. Our hypothesis is that meibomian gland
loss, which occurs in some forms of chronic blepharitis, leads to altered
meibomian gland function, increased evaporation from the ocular surface,
and increased tear osmolarity. By careful analysis of the data obtained
on these blepharitis patients, we also hope to achieve a better under-
standing of the characteristics of the blepharitis subsets and of the
interrelationship between meibomian gland function (gland dropout, volume
and viscosity) and the evaporative state (tear evaporation, osmolarity,
and tear flow).
To achieve these goals we will test our hypothesis by the following
specific aims: 1) We will establish the range of normal meibomian gland
function on the evaporative state of the eye for 150 patients over a rang
in ages. We will measure five quantitative variables: meibomian gland
dropout, evaporation rate, tear osmolarity, and tear flow by fluoropho-
tometry, and two qualitative variables: excreta volume and viscosity. 2)
We will establish the range of meibomian gland function in 150 patients
with chronic blepharitis measuring the same variables and using the same
age and sex distribution. 3) We will determine the correlation between
evaporation rate and gland dropout, tear osmolarity, tear flow and excre-
ta volume and viscosity in these 150 chronic blepharitis patients using
the data collected above. 4) We will investigate the effect of induced
meibomian gland dysfunction resulting from systemic Isotretinoin (accu-
tane) on tear evaporation, osmolarity, and tear flow before, during and
after treatment in 30 patients by measuring these same variables. 5) We
will use our data to characterize better the subsets which comprise ble-
pharitis by applying cluster analysis to the large data base collected
from these 150 patients with blepharitis.
我们的目标是了解慢性睑缘炎,睑板的作用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
WILLIAM D MATHERS其他文献
WILLIAM D MATHERS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('WILLIAM D MATHERS', 18)}}的其他基金
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
- 批准号:
6614375 - 财政年份:2003
- 资助金额:
$ 14.77万 - 项目类别:
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
- 批准号:
6732733 - 财政年份:2003
- 资助金额:
$ 14.77万 - 项目类别:
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
- 批准号:
6874846 - 财政年份:2003
- 资助金额:
$ 14.77万 - 项目类别:
MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
慢性睑缘炎的睑板腺功能障碍
- 批准号:
3267372 - 财政年份:1992
- 资助金额:
$ 14.77万 - 项目类别: