MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS

慢性睑缘炎的睑板腺功能障碍

基本信息

  • 批准号:
    2163864
  • 负责人:
  • 金额:
    $ 14.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1992
  • 资助国家:
    美国
  • 起止时间:
    1992-09-30 至 1995-09-29
  • 项目状态:
    已结题

项目摘要

Our goal is to understand chronic blepharitis, the role of the meibomian gland in blepharitis and the effect of meibomian gland loss on the dynamics of ocular evaporation. Our hypothesis is that meibomian gland loss, which occurs in some forms of chronic blepharitis, leads to altered meibomian gland function, increased evaporation from the ocular surface, and increased tear osmolarity. By careful analysis of the data obtained on these blepharitis patients, we also hope to achieve a better under- standing of the characteristics of the blepharitis subsets and of the interrelationship between meibomian gland function (gland dropout, volume and viscosity) and the evaporative state (tear evaporation, osmolarity, and tear flow). To achieve these goals we will test our hypothesis by the following specific aims: 1) We will establish the range of normal meibomian gland function on the evaporative state of the eye for 150 patients over a rang in ages. We will measure five quantitative variables: meibomian gland dropout, evaporation rate, tear osmolarity, and tear flow by fluoropho- tometry, and two qualitative variables: excreta volume and viscosity. 2) We will establish the range of meibomian gland function in 150 patients with chronic blepharitis measuring the same variables and using the same age and sex distribution. 3) We will determine the correlation between evaporation rate and gland dropout, tear osmolarity, tear flow and excre- ta volume and viscosity in these 150 chronic blepharitis patients using the data collected above. 4) We will investigate the effect of induced meibomian gland dysfunction resulting from systemic Isotretinoin (accu- tane) on tear evaporation, osmolarity, and tear flow before, during and after treatment in 30 patients by measuring these same variables. 5) We will use our data to characterize better the subsets which comprise ble- pharitis by applying cluster analysis to the large data base collected from these 150 patients with blepharitis.
我们的目标是了解慢性睑缘炎,睑板的作用

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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WILLIAM D MATHERS其他文献

WILLIAM D MATHERS的其他文献

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{{ truncateString('WILLIAM D MATHERS', 18)}}的其他基金

In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
  • 批准号:
    6614375
  • 财政年份:
    2003
  • 资助金额:
    $ 14.77万
  • 项目类别:
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
  • 批准号:
    6732733
  • 财政年份:
    2003
  • 资助金额:
    $ 14.77万
  • 项目类别:
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
  • 批准号:
    6874846
  • 财政年份:
    2003
  • 资助金额:
    $ 14.77万
  • 项目类别:
ENHANCED DIAGNOSIS OF ACANTHAMOEBA KERATITIS
棘阿米巴角膜炎的增强诊断
  • 批准号:
    2020181
  • 财政年份:
    1997
  • 资助金额:
    $ 14.77万
  • 项目类别:
ENHANCED DIAGNOSIS OF ACANTHAMOEBA KERATITIS
棘阿米巴角膜炎的增强诊断
  • 批准号:
    6038248
  • 财政年份:
    1997
  • 资助金额:
    $ 14.77万
  • 项目类别:
ENHANCED DIAGNOSIS OF ACANTHAMOEBA KERATITIS
棘阿米巴角膜炎的增强诊断
  • 批准号:
    2711206
  • 财政年份:
    1997
  • 资助金额:
    $ 14.77万
  • 项目类别:
TEAR FUNCTION IN BLEPHARITIS AND DRY EYE
睑缘炎和干眼症的泪液功能
  • 批准号:
    6164679
  • 财政年份:
    1992
  • 资助金额:
    $ 14.77万
  • 项目类别:
TEAR FUNCTION IN BLEPHARITIS AND DRY EYE
睑缘炎和干眼症的泪液功能
  • 批准号:
    6038247
  • 财政年份:
    1992
  • 资助金额:
    $ 14.77万
  • 项目类别:
MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
慢性睑缘炎的睑板腺功能障碍
  • 批准号:
    3267372
  • 财政年份:
    1992
  • 资助金额:
    $ 14.77万
  • 项目类别:
TEAR FUNCTION IN BLEPHARITIS AND DRY EYE
睑缘炎和干眼症的泪液功能
  • 批准号:
    2608653
  • 财政年份:
    1992
  • 资助金额:
    $ 14.77万
  • 项目类别:
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