TEAR FUNCTION IN BLEPHARITIS AND DRY EYE

睑缘炎和干眼症的泪液功能

基本信息

  • 批准号:
    6164679
  • 负责人:
  • 金额:
    $ 22.89万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1992
  • 资助国家:
    美国
  • 起止时间:
    1992-09-30 至 2002-02-28
  • 项目状态:
    已结题

项目摘要

Blepharitis is the most common cause of visits to the ophthalmologist's office outside of refractive error. We hypothesize that meibomian gland dysfunction, with alterations in meibomian lipid composition, plays a major role in blepharitis and in dry eye through evaporation effects. Understanding these changes will aid in developing therapies and designing lipid substitutes. Dry eye is more frequent in women, and is also one of the most common presenting complaints in ophthalmology. In our previous grant we developed methods for accurately measuring tear flow, osmolarity, evaporation, and meibomian gland function. We found that almost all tear film functions decline with age. We also found with age a greater loss of lacrimal capacity in women than men. We hypothesize there is significant hormonal influence on tear function, in addition to the decline in function with age. The overall purpose of this grant is to proceed with this work on the tear film, blepharitis, and dry eye. Specific Aim: l) Assess the influence of sex hormones on tear function in humans. 1a) Study the effects of normal and abnormal androgen levels on tear function. 1b) Evaluate the effects of normal and abnormal estrogen levels on tear function. 1c) Evaluate the effects of abnormal prolactin levels on tear function. Specific Aim: 2) Determine the correlation between changes in lipid composition and the resulting clinical and physiologic parameters of tear film function. Evaluate the changes in composition of meibomian lipid which occur with 2a) age, 2b) specific meibomian gland disease states, 2c) altered evaporative rate. 2d) Evaluate patients with Rosacea and seborrheic dermatitis to determine the effects of these dermatologic diseases on the tear film. 2e) Refine our classification of blepharitis and tear function using 2a-d data. 2f) Evaluate tear function following the addition of various lipids to the tear film layer. Specific Aim: 3 correlated tear film function with the confocal appearance of the tear film lipid surface in normals, disease states and contact lens use. 3a) Refine tandem scanning confocal microscopy of the lipid layer 3b) correlate altered functions of the tear film found in disease states with the confocal microscopic appearance 3c) Use confocal microscopy and evaporation measurements to investigate the tear film changes which occur with contact lenses.
Blepharitis is the most common cause of visits to the ophthalmologist's office outside of refractive error. We hypothesize that meibomian gland dysfunction, with alterations in meibomian lipid composition, plays a major role in blepharitis and in dry eye through evaporation effects. Understanding these changes will aid in developing therapies and designing lipid substitutes. Dry eye is more frequent in women, and is also one of the most common presenting complaints in ophthalmology. In our previous grant we developed methods for accurately measuring tear flow, osmolarity, evaporation, and meibomian gland function. We found that almost all tear film functions decline with age. We also found with age a greater loss of lacrimal capacity in women than men. We hypothesize there is significant hormonal influence on tear function, in addition to the decline in function with age. The overall purpose of this grant is to proceed with this work on the tear film, blepharitis, and dry eye. Specific Aim: l) Assess the influence of sex hormones on tear function in humans. 1a) Study the effects of normal and abnormal androgen levels on tear function. 1b) Evaluate the effects of normal and abnormal estrogen levels on tear function. 1c) Evaluate the effects of abnormal prolactin levels on tear function. Specific Aim: 2) Determine the correlation between changes in lipid composition and the resulting clinical and physiologic parameters of tear film function. Evaluate the changes in composition of meibomian lipid which occur with 2a) age, 2b) specific meibomian gland disease states, 2c) altered evaporative rate. 2d) Evaluate patients with Rosacea and seborrheic dermatitis to determine the effects of these dermatologic diseases on the tear film. 2e) Refine our classification of blepharitis and tear function using 2a-d data. 2f) Evaluate tear function following the addition of various lipids to the tear film layer. Specific Aim: 3 correlated tear film function with the confocal appearance of the tear film lipid surface in normals, disease states and contact lens use. 3a) Refine tandem scanning confocal microscopy of the lipid layer 3b) correlate altered functions of the tear film found in disease states with the confocal microscopic appearance 3c) Use confocal microscopy and evaporation measurements to investigate the tear film changes which occur with contact lenses.

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A study of aqueous humor dynamics in keratoconus.
圆锥角膜房水动力学的研究。
  • DOI:
    10.1006/exer.1996.0011
  • 发表时间:
    1996
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Goodman,WT;Mathers,WD;Munden,PM;Ossoinig,KC;Daley,TE
  • 通讯作者:
    Daley,TE
In vivo observation of the human tear film by tandem scanning confocal microscopy.
通过串联扫描共焦显微镜对人泪膜进行活体观察。
  • DOI:
  • 发表时间:
    1994
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mathers,WD;Daley,TE
  • 通讯作者:
    Daley,TE
Meibomian gland lipids, evaporation, and tear film stability.
睑板腺脂质、蒸发和泪膜稳定性。
Assessment of the tear film with tandem scanning confocal microscopy.
用串联扫描共焦显微镜评估泪膜。
  • DOI:
  • 发表时间:
    1997
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mathers,WD;Lane,JA;Zimmerman,MB
  • 通讯作者:
    Zimmerman,MB
Diagnosis of aspergillus keratitis in vivo with confocal microscopy
  • DOI:
    10.1097/00003226-199701000-00006
  • 发表时间:
    1997-01-01
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Winchester, K;Mathers, WD;Sutphin, JE
  • 通讯作者:
    Sutphin, JE
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WILLIAM D MATHERS其他文献

WILLIAM D MATHERS的其他文献

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{{ truncateString('WILLIAM D MATHERS', 18)}}的其他基金

In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
  • 批准号:
    6614375
  • 财政年份:
    2003
  • 资助金额:
    $ 22.89万
  • 项目类别:
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
  • 批准号:
    6732733
  • 财政年份:
    2003
  • 资助金额:
    $ 22.89万
  • 项目类别:
In Vivo Imaging of Leukocyte-Endothelial Dynamics
白细胞内皮动力学的体内成像
  • 批准号:
    6874846
  • 财政年份:
    2003
  • 资助金额:
    $ 22.89万
  • 项目类别:
ENHANCED DIAGNOSIS OF ACANTHAMOEBA KERATITIS
棘阿米巴角膜炎的增强诊断
  • 批准号:
    2020181
  • 财政年份:
    1997
  • 资助金额:
    $ 22.89万
  • 项目类别:
ENHANCED DIAGNOSIS OF ACANTHAMOEBA KERATITIS
棘阿米巴角膜炎的增强诊断
  • 批准号:
    6038248
  • 财政年份:
    1997
  • 资助金额:
    $ 22.89万
  • 项目类别:
ENHANCED DIAGNOSIS OF ACANTHAMOEBA KERATITIS
棘阿米巴角膜炎的增强诊断
  • 批准号:
    2711206
  • 财政年份:
    1997
  • 资助金额:
    $ 22.89万
  • 项目类别:
MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
慢性睑缘炎的睑板腺功能障碍
  • 批准号:
    2163864
  • 财政年份:
    1992
  • 资助金额:
    $ 22.89万
  • 项目类别:
TEAR FUNCTION IN BLEPHARITIS AND DRY EYE
睑缘炎和干眼症的泪液功能
  • 批准号:
    6038247
  • 财政年份:
    1992
  • 资助金额:
    $ 22.89万
  • 项目类别:
MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS
慢性睑缘炎的睑板腺功能障碍
  • 批准号:
    3267372
  • 财政年份:
    1992
  • 资助金额:
    $ 22.89万
  • 项目类别:
TEAR FUNCTION IN BLEPHARITIS AND DRY EYE
睑缘炎和干眼症的泪液功能
  • 批准号:
    2608653
  • 财政年份:
    1992
  • 资助金额:
    $ 22.89万
  • 项目类别:

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