TEAR FUNCTION IN BLEPHARITIS AND DRY EYE

眼缘炎是眼科医生就诊的最常见原因 办公室外屈光不正。我们假设眉毛腺 功能障碍，伴随着眉毛脂肪成分的变化，发挥着 主要通过蒸发作用在眼睑炎症和干眼症中发挥作用。 了解这些变化将有助于开发治疗方法和设计 脂肪替代品。干眼症在女性中更为常见，也是 眼科最常见的主诉。在我们之前的 格兰特，我们开发了精确测量泪液流量，渗透压， 蒸发，和眉毛腺的功能。我们发现几乎所有的眼泪 电影的功能随着年龄的增长而衰退。我们还发现，随着年龄的增长， 女性的泪腺容量高于男性。我们假设有重要意义的 荷尔蒙对泪液功能的影响，除了 随着年龄的增长而发挥作用。这笔赠款的总体目的是继续进行 这项工作是关于泪膜、眼睑发炎和干眼症。具体目标：L) 评估性激素对人类泪液功能的影响。1A)研究 雄激素水平正常与异常对泪液功能的影响1B) 评价雌激素水平正常和异常对泪液的影响 功能。1C)评估催乳素水平异常对泪液的影响 功能。具体目标：2)确定以下变化之间的相关性 脂类成分及由此产生的临床和生理参数 泪膜功能。评价眉眠成分的变化 与2a)年龄、2b)特异性眉板腺疾病有关的脂类 状态，2c)改变蒸发速率。2D)评估酒渣鼻患者 和脂溢性皮炎来确定这些皮肤病的效果 泪膜上的疾病。2E)完善我们对眼缘炎的分类 以及使用2a-d数据的撕裂函数。2F)术后评估撕裂功能 在泪膜层中添加各种脂类。具体目标：3 泪膜功能与泪液共聚焦现象的相关性 膜脂表面在正常、疾病状态下和隐形眼镜使用。3A) 改进脂肪层3b的串联扫描共聚焦显微镜) 在疾病状态下发现的泪膜功能改变与 共聚焦显微镜外观3)使用共聚焦显微镜和 蒸发测量以研究泪膜发生的变化 戴着隐形眼镜。

Blepharitis is the most common cause of visits to the ophthalmologist's office outside of refractive error. We hypothesize that meibomian gland dysfunction, with alterations in meibomian lipid composition, plays a major role in blepharitis and in dry eye through evaporation effects. Understanding these changes will aid in developing therapies and designing lipid substitutes. Dry eye is more frequent in women, and is also one of the most common presenting complaints in ophthalmology. In our previous grant we developed methods for accurately measuring tear flow, osmolarity, evaporation, and meibomian gland function. We found that almost all tear film functions decline with age. We also found with age a greater loss of lacrimal capacity in women than men. We hypothesize there is significant hormonal influence on tear function, in addition to the decline in function with age. The overall purpose of this grant is to proceed with this work on the tear film, blepharitis, and dry eye. Specific Aim: l) Assess the influence of sex hormones on tear function in humans. 1a) Study the effects of normal and abnormal androgen levels on tear function. 1b) Evaluate the effects of normal and abnormal estrogen levels on tear function. 1c) Evaluate the effects of abnormal prolactin levels on tear function. Specific Aim: 2) Determine the correlation between changes in lipid composition and the resulting clinical and physiologic parameters of tear film function. Evaluate the changes in composition of meibomian lipid which occur with 2a) age, 2b) specific meibomian gland disease states, 2c) altered evaporative rate. 2d) Evaluate patients with Rosacea and seborrheic dermatitis to determine the effects of these dermatologic diseases on the tear film. 2e) Refine our classification of blepharitis and tear function using 2a-d data. 2f) Evaluate tear function following the addition of various lipids to the tear film layer. Specific Aim: 3 correlated tear film function with the confocal appearance of the tear film lipid surface in normals, disease states and contact lens use. 3a) Refine tandem scanning confocal microscopy of the lipid layer 3b) correlate altered functions of the tear film found in disease states with the confocal microscopic appearance 3c) Use confocal microscopy and evaporation measurements to investigate the tear film changes which occur with contact lenses.