Biochemical production of succinic acid from biorefinery glycerol: De-risking, scale-up, and feasibility

从生物精炼甘油生化生产琥珀酸：降低风险、扩大规模和可行性

• 批准号: 131835
• 金额: $ 13.76万
• 依托单位: THE UNIVERSITY OF MANCHESTER
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131835
• 关键词: Biochemical; production; succinic; acid; biorefinery

This project addresses the production of succinic acid (SA), a top-added value chemical, through the fermentation of crude glycerol, the main biodiesel byproduct. Currently, SA is manufactured from petrochemicals or by fermentation of glucose. The bioconversion of crude glycerol will valorise this renewable side-stream, significantly improving the biorefinery economy, and providing an economic, sustainable SA production route with reduced carbon footprint. A combination of experimental methods at a range of scales, computational tools, and market analysis will be employed in order to: prove the feasibility of the downstream process, benchmark the succinic acid product against market standards, optimise the scale up of the fermentation process and identify and engage commercial end users. The aim is to make a significant step in reducing the risk of the proposed bioprocess to attract industrial investments, hence moving closer towards its industrial uptake and application.

该项目致力于通过发酵主要生物柴油副产品粗甘油来生产琥珀酸(SA)，这是一种最高附加值的化学品。目前，SA是从石化产品或葡萄糖发酵中生产出来的。粗甘油的生物转化将使这一可再生副流失效，显著改善生物炼油经济，并提供一条经济、可持续的SA生产路线，减少碳足迹。将使用各种规模的实验方法、计算工具和市场分析相结合的方法，以：证明下游工艺的可行性，对照市场标准对丁二酸产品进行基准测试，优化发酵过程的放大，并确定并吸引商业最终用户。其目的是在降低拟议生物工艺的风险方面迈出重要的一步，以吸引工业投资，从而更接近其工业吸收和应用。