Sustainable Succinic Acid Production using an Integrated Electrochemical Bioreactor and Renewable Feedstock

项目摘要：Lucra将利用欧盟未得到充分利用和丰富的城市固体废物和木材废物作为原料，利用循环生物经济生物精炼方法，以高产量大规模生产具有重大工业最终用户兴趣的平台积木生物基化学品。它将在TRL7提供优化和可扩展的创新技术，实现从中试到大规模集成发酵的阶段性转变，并在TRL7电化学法提取琥珀酸(SA)，这将促进其工业实施、商业模式和市场可行性。这将通过循环利用上述可再生资源作为原料来实现，这将在很大程度上减少对化石资源的依赖，同时实现一条可持续的SA生产路线。为了适应工业水平的需要，Lucra将对不同原料的水解过程进行优化，以获得高效的纤维素和半纤维素转化。将展示酶鸡尾酒，旨在最大限度地利用低抑制剂生产可发酵碳水化合物的水解物。富含粗糖的水解液将作为发酵原料，在电化学膜生物反应器中进行高效提取和生产SA。通过阴离子交换膜实现了对SA的原位萃取，实现了同时酸化、浓缩，降低了调节pH的NaOH消耗，减少了SA提纯的单元操作。为了展示生产的SA将能够与石化过程中基于化石的同类产品直接竞争，将以半工业规模生产不同的聚氨酯分散体和树脂。在Lucra实施的过程旨在降低BIO-SA的成本，并将证明比传统SA减少50%的温室气体排放

Project summary: Project summary LUCRA will exploit the EU’s underutilized and abundant, Municipal Solid Waste and Wood waste as feedstocks for the large scale production of platform building block biobased chemicals at high yield with significant industrial end-user interest using a circular bioeconomy biorefinery approach. It will provide optimized and scaleable ‘breakthrough first of a kind’ innovative technology to create a step change from pilot to large scale integrated fermentation with novel electrochemical extraction of succinic acid (SA) at TRL7 that will facilitate its industrial implementation, business models and market feasibility. This will be achieved by the circular utilization of the mentioned renewable resources as feedstocks which will reduce to a large extent the dependence on fossil resources and achieves at the same time a sustainable SA production route. To fit the needs of the industrial level, LUCRA will optimize the hydrolysis process of the different feedstocks to obtain efficient cellulose and hemicellulose conversion. Enzymatic cocktails will be demonstrated aiming to maximize hydrolysis of fermentable carbohydrate content with low inhibitors production. The crude sugar-rich hydrolysates will be used as fermentation feedstock in an electrochemical membrane bioreactor for efficient extraction and production of SA. In situ extraction of SA will be achieved through an anion exchange membrane resulting in simultaneous acidification, concentration, lower NaOH consumption for pH regulation and less unit operations for SA purification. To demonstrated the produced SA that will be able to compete directly their fossil-based counterparts from petrochemical processes, different polyurethane dispersions and resins will be produced at semi-industrial scale. The process implemented in LUCRA targeting to reduce the cost of bio-SA and will demonstrate an 50% GHG reduction against conventional SA