ALTERED HEPATIC DISPOSITION OF ANIONIC DRUGS--MECHANISM

改变阴离子药物的肝脏处置——机制

• 批准号: 2181140
• 负责人: KIM L.R. BROUWER
• 金额: $ 11.04万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2181140
• 关键词: ALTERED; HEPATIC; DISPOSITION; ANIONIC; DRUGS

项目成果

Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats.

多药耐药相关蛋白 2 缺陷 (TRα) 大鼠中肝癌耐药蛋白表达和功能降低。

• DOI: 10.1124/dmd.110.035188
• 发表时间: 2011
• 期刊: Drug metabolism and disposition: the biological fate of chemicals
• 作者: Yue,Wei;Lee,JinKyung;Abe,Koji;Sugiyama,Yuichi;Brouwer,KimLR
• 通讯作者: Brouwer,KimLR

P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.

• 发表时间: 2001-10
• 期刊: Drug metabolism and disposition: the biological fate of chemicals
• 作者: Pieter Annaert;Ryan Z. Turncliff;Catherine Booth;D. Thakker;Kim L. R. Brouwer

Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment.

急性苯巴比妥治疗和体内苯巴比妥预处理后，离体灌注大鼠肝脏中对乙酰氨基酚葡萄糖醛酸的胆汁排泄受损。

• 发表时间: 1992
• 期刊: The Journal of pharmacology and experimental therapeutics
• 作者: Studenberg,SD;Brouwer,KL
• 通讯作者: Brouwer,KL

Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase.

固定化大鼠肝 UDP-葡萄糖醛酸基转移酶产生的对羟基苯巴比妥葡萄糖醛酸苷的表征。

• DOI: 10.1002/jps.2600840918
• 发表时间: 1995
• 期刊: Journal of pharmaceutical sciences
• 影响因子: 3.8
• 作者: Studenberg,SD;Price-Raybuck,DL;Unger,SE;Shockcor,J;Brouwer,KL
• 通讯作者: Brouwer,KL

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.

急性苯巴比妥治疗或苯巴比妥预处理后对乙酰氨基酚葡萄糖苷酸胆汁排泄受损的机制。

• 发表时间: 2002
• 期刊: Drug Metab Dispos 30
• 作者: Xiong H. et al.