An investigation into the feasibility of fabrication of inkjet SERS sensors to detect bacteria in sputum samples for the early detection of excerbations in chronic obstructive pulmonary disease (COPD)

研究制造喷墨 SERS 传感器来检测痰样本中的细菌，以早期检测慢性阻塞性肺病 (COPD) 的恶化

• 批准号: 131971
• 金额: $ 2.94万
• 依托单位: APPLIED NANODETECTORS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131971
• 关键词: investigation; into; feasibility; fabrication; inkjet

Chronic obstructive pulmonary disease (COPD) is a prevalent lung disease (3 Million in UK) that accounts for a major burden in the UK in terms of morbidity (25,000 deaths a year) and health care costs (£4bn). COPD is punctuated by exacerbations which are episodes of increased respiratory symptoms associated with systemic and airway inflammation. Most exacerbations however are either triggered by viral or bacterial infection, a diagnostic test which could confirm the presence of of pathogenic airway bacteria would be useful in helping guide physicians in prescribing appropriate medication. In this project we will investigate the viability of using a nanomaterial based printed SERS sensor array to detect bacteria in sputum samples to predict the onset of exacerbations. We will use SERS for identification and discrimination of bacteria based on their detected spectral fingerprints.

慢性阻塞性肺疾病（COPD）是一种普遍的肺部疾病（在英国有300万人），在发病率（每年25,000人死亡）和医疗费用（40亿英镑）方面，它是英国的主要负担。慢性阻塞性肺病有时会加重，即与全身和气道炎症相关的呼吸系统症状加重。然而，大多数恶化是由病毒或细菌感染引起的，一种能够确认致病性气道细菌存在的诊断测试将有助于指导医生开出适当的药物。在这个项目中，我们将研究使用基于纳米材料的打印SERS传感器阵列来检测痰样本中的细菌以预测恶化的发生的可行性。我们将基于检测到的光谱指纹，利用SERS对细菌进行识别和鉴别。