VISCERAL NEURAXIS IN HOMEOSTASIS
体内平衡中的内脏神经轴
基本信息
- 批准号:2174997
- 负责人:
- 金额:$ 24.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1980
- 资助国家:美国
- 起止时间:1980-09-25 至 1995-03-31
- 项目状态:已结题
- 来源:
- 关键词:autonomic nervous system brain mapping cholera toxin eating fluorescent dye /probe gastrointestinal system histochemistry /cytochemistry homeostasis hypothalamus immunocytochemistry innervation laboratory rat neural information processing neuroanatomy neuroendocrine system neurogenic hypertension neuropeptides neuropsychology nutrition related tag obesity peroxidases psychobiology schizophrenia supraoptic nucleus thirst regulatory center vagus nerve visceral afferent nerve water drinking behavior
项目摘要
The visceral neuraxis of the mammalian brain is a network of neural
connections that mediates the behavioral and physiological controls of
homeostasis. It can be defined neuroanatomically by its connections to the
autonomic nervous system, connections with circumventricular organs of the
brain and connections to the major hypothalamic nuclei affecting endocrine
function as well as by interconnections of intervening nuclei. The
circumventricular organs, which lack a blood brain barrier making them
putative central receptor sites for humoral factors affecting visceral
function, and the visceral afferents (chemoreceptors, baroreceptors and
mechanoreceptors) of the peripheral nervous system make up the sensory side
of the network. The motor components are the autonomic nervous system,
endocrine system and homeostatic behavior. The long term objectives of
this project are to define and understand the operation of the components
of the visceral neuraxis contributing to the generation of ingestive
behaviors and specific behavioral states and the factors which convert them
into health damaging behaviors or states that accompany obesity,
schizophrenia, hypertension, psychogenic polydipsia, stress ulcers, and
essential hypernatremia. The first specific objective is to complete the
viscerotopic mapping and immunocytochemical characterization of the
brainstem's innervation of organs of the alimentary canal. Neuroanatomical
studies (single and double labeling) at the light and electron microscopic
level will be done using conjugates, particularly cholera toxin, of
horseradish peroxidase, fluorescent dyes, dye tagged lectins, toxins and
antibodies to neuropeptides. The goal is to determine how incoming
visceral afferent information is routed and modified by neuropeptides for
local control of viscera and for influencing behavior. The second goal is
to determine at the ultrastructural level how gastric afferents which
presumably play a role in satiation distribute to neurons that project up
the visceral neuraxis and to neurons that remain connected locally. The
third goal is to determine at the ultrastructural level using a double
labeling technique how descending projections from the hypothalamus to the
vagal complex influence the input and processing of visceral afferent
information through the visceral neuraxis for use in behavior. The fourth
goal is to determine the effects of microlesioning pathways and terminal
field sites of new projections from the subfornical organ on drinking
behavior and renal function in response to thirst challenges.
哺乳动物大脑的内脏神经轴是一个神经网络,
连接,介导的行为和生理控制,
体内平衡 从神经解剖学上讲,它可以通过与
自主神经系统,与室周器官的联系
大脑和连接到影响内分泌的主要下丘脑核团
以及通过中间原子核的相互连接来发挥作用。 的
脑室周围器官,缺乏血脑屏障,
影响内脏功能的体液因子的假定中枢受体位点
功能和内脏传入(化学感受器,压力感受器和
周围神经系统的机械感受器(mechanoreceptors)组成感觉侧
网络的一部分。 运动部分是自主神经系统,
内分泌系统和稳态行为。 的长期目标
这个项目是为了定义和理解组件的操作
的内脏神经轴有助于产生摄食
行为和特定的行为状态以及转换它们的因素
健康损害行为或伴随肥胖的状态,
精神分裂症、高血压、心因性烦渴、应激性溃疡,以及
原发性高钠血症 第一个具体目标是完成
内脏定位和免疫细胞化学表征的
脑干对消化道器官的神经支配。 神经解剖
光镜和电镜下的研究(单标记和双标记)
水平将使用缀合物,特别是霍乱毒素,
辣根过氧化物酶、荧光染料、染料标记的凝集素、毒素和
神经肽抗体 我们的目标是确定
内脏传入信息被神经肽路由和修改,
局部控制内脏和影响行为。 第二个目标是
以确定在超微结构水平上胃传入神经,
可能在饱足感分布到向上投射神经元中起作用
内脏神经轴和保持局部连接的神经元。 的
第三个目标是在超微结构水平上使用双
标记技术如何从下丘脑下行投射到
迷走神经复合体影响内脏传入神经的传入和加工
通过内脏神经轴传递信息用于行为。 第四
目的是确定微损伤途径和终末
穹窿下器官对饮酒的新投射部位
行为和肾功能对口渴挑战的反应。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RICHARD R MISELIS其他文献
RICHARD R MISELIS的其他文献
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{{ truncateString('RICHARD R MISELIS', 18)}}的其他基金
CIRCUMVENTRICULAR ORGANS--MODULATORS OF HOMEOSTASIS
心室周围器官——体内平衡的调节器
- 批准号:
3274983 - 财政年份:1980
- 资助金额:
$ 24.94万 - 项目类别:
CIRCUMVENTRICULAR ORGANS--MODULATORS OF HOMEOSTASIS
心室周围器官——体内平衡的调节器
- 批准号:
3274986 - 财政年份:1980
- 资助金额:
$ 24.94万 - 项目类别:
CIRCUMVENTRICULAR ORGANS--MODULATORS OF HOMEOSTASIS
心室周围器官——体内平衡的调节器
- 批准号:
3274987 - 财政年份:1980
- 资助金额:
$ 24.94万 - 项目类别:
CIRCUMVENTRICULAR ORGANS--MODULATORS OF HOMEOSTASIS
心室周围器官——体内平衡的调节器
- 批准号:
3274985 - 财政年份:1980
- 资助金额:
$ 24.94万 - 项目类别:
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