APPROACHES TO CHIRAL CARBON AND NITROGEN COMPOUNDS

手性碳氮化合物的研究方法

• 批准号: 2177357
• 负责人: ALBERT I MEYERS
• 金额: $ 20.55万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2177357
• 关键词: alkylation; biological products; chemical addition; chemical synthesis; cyclization; ketoacid; lactams; oxidation reduction reaction; piperidine; pyrrolidines; stereoisomer

DESCRIPTION: The principal investigator states that the program to continue to evaluate the synthetic properties of chiral, non-racemic bicyclic lactams is presented. He notes that the lactams, derived from optically active amino alcohols (by reduction of amino acids) and 3- or 4-ketocarboxylic acids provide a chiral template upon which to perform an unusual number of synthetic reactions: alkylations, additions, cycloadditions (photo, thermal, acid-catalyzed), reductions, oxidations, and others. He further indicates that the products of these chemical reactions lead to a plethora of enantiomerically pure quaternary carbon compounds, many of which are natural products with important biological activity. It is noted that the present proposal will extend these studies to contiguous chiral centers, chiral pyrrolidines and piperidines. The latter are said to be important core systems in a number of biologically active compounds.

描述：首席研究员声明，该计划