APPROACHES TO CHIRAL CARBON AND NITROGEN COMPOUNDS

描述：首席调查员表示，该计划将 继续评价手性、非外消旋化合物的合成性能 介绍了双环内酰胺类药物。他指出，内酰胺类药物源自 光学活性氨基醇(通过氨基酸还原)和3-或 4-酮羧酸提供了一种手性模板 不同寻常的合成反应：烷基化，加成， 环加成反应(光、热、酸催化)、还原、氧化、 还有其他人。他进一步指出，这些化学品的产品 反应生成大量对映体纯的季碳。 化合物，其中许多是具有重要生物学意义的天然产物 活动。需要指出的是，目前的提案将延长这些 邻位手性中心、手性吡咯烷和 哌啶类药物。后者被认为是 生物活性化合物的数量。

DESCRIPTION: The principal investigator states that the program to continue to evaluate the synthetic properties of chiral, non-racemic bicyclic lactams is presented. He notes that the lactams, derived from optically active amino alcohols (by reduction of amino acids) and 3- or 4-ketocarboxylic acids provide a chiral template upon which to perform an unusual number of synthetic reactions: alkylations, additions, cycloadditions (photo, thermal, acid-catalyzed), reductions, oxidations, and others. He further indicates that the products of these chemical reactions lead to a plethora of enantiomerically pure quaternary carbon compounds, many of which are natural products with important biological activity. It is noted that the present proposal will extend these studies to contiguous chiral centers, chiral pyrrolidines and piperidines. The latter are said to be important core systems in a number of biologically active compounds.